张跃林，博士生导师，国家特聘专家。

联系方式：Email: yuelin.zhang@scu.edu.cn

研究方向：植物分子遗传学，植物免疫，系统获得性抗性，核盘菌致病机理与作物抗病的分子设计。

简介：四川大学特聘教授（全职）。加入四川大学之前，先后任职于北京生命科学研究所（研究员/高级研究员），加拿大英属哥伦比亚大学（终身教授）。长期从事植物系统获得性抗性以及植物免疫受体下游信号转导通路的研究，通过遗传学手段筛选出一系列在植物免疫反应的信号转导中起着关键调控作用的因子，并进一步解析了它们调控植物免疫反应的分子机制。在Cell, Nature, Science, Cell Host & Microbe, Nature Communication, PNAS, Plant Cell等国际一流杂志上发表论文100余篇，被引用22000余次。现为Horticulture Research副主编。

代表性论文：（*为通讯）

Liu, Y., Xu, L., Wu, M., Wang, J., Qiu, D., Lan, J., Lu, J., Zhang, Y., Li, X. and Zhang, Y.* (2025) Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants. Nature, 645: 201–207.

Xu, Y., Tian, L., Tan, J., Huang, W., Li, J., O’Neil, N., Hirst, M., Hieter, P., Zhang, Y.* and Li, X.* (2025) Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi. Science, 388: 784-788.

Tian, H., Xu, L., Li, X., and Zhang, Y.* (2025). Salicylic acid: The roles in plant immunity and crosstalk with other hormones. Journal of Integrative Plant Biology, 67: 773-785.

Zhang, C., Xu, Y., Li, L., Wu, M., Fang, Z., Tan, J., Rollins, J.A., Lin, H., Huang, X., Mansfield, S.D., Li, X.*, and Zhang, Y.* (2025) A GDP-mannose-1-phosphate guanylyltransferase as a potential HIGS target against Sclerotinia sclerotiorum. PLoS Pathogens, 21(5), p.e1013129.

Wu, D., Tian, H., Xu, F., Yang, J., Feng, W., Bell, S., Gozdzik, J., Gao, F., Jetter, R. and Zhang, Y.* (2024) The prodomain of Arabidopsis metacaspase 2 positively regulates immune signaling mediated by pattern-recognition receptors. New Phytologist, 241:430-443.

Xu, Y., Tan, J., Lu, J., Zhang, Y.* and Li, X.* (2024) RAS signalling genes can be used as host‐induced gene silencing targets to control fungal diseases caused by Sclerotinia sclerotiorum and Botrytis cinerea. Plant Biotechnology Journal, 262-277.

Lan, J., Chen, S., Pico, J., Ao, K., Xia, S., Wang, S., Li, X., Castellarin, S.D. and Zhang, Y.* (2023) Epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex. Journal of Integrative Plant Biology, 65:2660-2671.

Tian, H., Chen, S., Wu, Z., Ao, K., Yaghmaiean, H., Sun, T., Huang, W., Xu, F., Zhang, Y., Wang, S., Li, X.*, and Zhang, Y.* (2021). Activation of TIR signaling boosts pattern-triggered immunity. Nature, https://doi.org/10.1038/s41586-021-03987-1.

Huang, W., Wu, Z., Tian, H., Li, X. and Zhang, Y.* (2021) Arabidopsis CALMODULIN-BINDING PROTEIN 60b plays dual roles in plant immunity. Plant communications, 2:100213.

Peng, Y., Yang, J., Li, X. and Zhang, Y.* (2021) Salicylic acid: Biosynthesis and Signaling. Annual Review in Plant Biology, 72:761-791.

Mohnike, L., Rekhter, D., Huang, W., Feussner, K., Tian, H., Herrfurth, C., Zhang, Y.* and Feussner, I*. (2021) The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant Immunity. Plant Cell, 33(3), 735-749.

Liu, Y., Sun, T., Sun, Y., Zhang, Y., Radojičić, A., Ding, Y., Tian, H., Huang, X., Lan, J., Chen, S. and Orduna, A.R., Zhang, K., Jetter, R., Li, X. and Zhang, Y.* (2020) Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity. Plant Cell, 32(12), 4002-4016.

Zhou, J.* and Zhang, Y.* (2020) Plant immunity: danger perception and signaling. Cell, 181(5): 978-989.

Huang, W., Wang, Y., Li, X. and Zhang, Y.* (2020) Biosynthesis and regulation of salicylic acid and N-hydroxypipecolic acid in plant immunity. Molecular Plant, 13 (1): 31-41.

Sun, T., Huang, J., Xu, Y., Verma, V., Jing, B., Sun, Y., Ordunac, A., Tian, H., Huang, X., Xia, S., Schaferc, L., Jetter, R., Zhang, Y.* and Li, X.* (2019) Redundant CAMTA transcription factors negatively regulate the biosynthesis of salicylic acid and N-hydroxypipecolic acid by modulating the expression of SARD1 and CBP60g. Molecular Plant, 13: 144-156.

Rekhter, D., Lüdke, D., Ding, Y., Feussner, K., Zienkiewicz, K., Lipka, V., Wiermer, M.*, Zhang, Y.* and Feussner, I*. (2019) Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid. Science, 365, 498-502.

Zhang, Y.* and Li, X. (2019) Salicylic acid: Biosynthesis, perception and contributions to plant immunity. Current Opinion in Plant Biology, 50:1-8.

Ding, Y., Sun, T., Ao, K., Peng, Y., Zhang, Y., Li, X. and Zhang, Y.* 2018. Opposite roles of salicylic acid receptors NPR1 and NPR3/NPR4 in transcriptional regulation of plant immunity. Cell, 173, 1454–1467.

Sun, T., Busta, L., Zhang, Q., Ding, P., Jetter, R. and Zhang, Y.* 2018. TGACG-BINDING FACTOR 1 (TGA1) and TGA4 regulate salicylic acid and pipecolic acid biosynthesis by modulating the expression of SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) and CALMODULIN-BINDING PROTEIN 60g (CBP60g). New Phytologist, 217: 344–354. doi:10.1111/nph.14780.

Ma C., Liu Y., Bai B., Han Z, Tang J., Zhang H., Yaghmaiean H., Zhang Y.* and Chai J.* 2017. Structural basis for BIR1-mediated negative regulation of plant immunity. Cell Research, 27, 1521–1524.

Ding, P., Rekhter, D., Ding, Y., Feussner, K., Busta, L., Haroth, S., Xu, S., Li, X., Jetter, R., Feussner, I.* and Zhang, Y.* 2016. Characterization of a pipecolic pcid biosynthesis pathway required for systemic acquired resistance. Plant Cell, 28: 2603–2615.

Zhang Z., Liu Y., Huang H., Gao M., Wu D., Kong Q. and Zhang Y.* 2016. Sensing the disruption of a MAP kinase cascade by an NLR protein through a MAP kinase substrate. EMBO Reports, pii: e201642704.

Liu, Y., Huang, X., Li, M., He, P. and Zhang, Y.* 2016. Loss-of-function of Arabidopsis receptor-like kinase BIR1 activates cell death and defense responses mediated by BAK1 and SOBIR1. New Phytologist, doi: 10.1111/nph.14072. [Epub ahead of print].

Kong, Q., Sun, T., Qu, N., Ma, J., Li, M., Cheng, Y.-t., Zhang, Q., Wu, D., Zhang, Z. and Zhang, Y.*2016. Two redundant receptor-like cytoplasmic kinases function downstream of pattern recognition receptors to regulate activation of SA biosynthesis in Arabidopsis. Plant Physiology, 171(2): 1344-1354.

Liang, X., Ding, P., Lian, K., Wang, J., Ma, M., Li, L., Li, L., Li, M., Zhang, X., Chen, S., Zhang, Y.* and Zhou, J.* 2016. Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. eLife 5, e13568.

Sun T., Zhang Y., Li Y., Zhang Q., Ding Y. and Zhang, Y.* 2015. ChIP-seq analysis reveals broad roles of SARD1 and CBP60g in regulating plant immunity. Nature Communications, 6:10159.

Zhang, Z., Liu, Y., Ding, P., Li, Y., Kong, Q. and Zhang, Y.* 2014. Splicing of Receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Molecular Plant, 7(12):1766-75.

Liu, J., Ding, P., Sun, T., Nitta, Y., Dong, O., Huang, X., Yang, W., Li, X., Botella, J. and Zhang, Y.* 2013. Heterotrimeric G proteins serve as a converging point in plant defense signaling activated by multiple receptor-like kinases. Plant Physiology, 161(4), 2146-2158.

Zhang Z., Wu Y., Gao M., Zhang J., Kong Q., Liu Y., Ba H., Zhou J.M. and Zhang Y.* 2012. Disruption of a PAMP-induced MAP Kinase Cascade Activates Plant Immunity Mediated by an NB-LRR Protein. Cell Host & Microbe,11(3):253-63.

Kong, Q., Qu, N., Gao, M., Zhang, Z., Ding, X., Yang, F., Li, Y., Dong, X., Chen, S., Li, X., and Zhang, Y. 2012. The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a MAP kinase kinase kinase. Plant Cell, 24(5):2225-36.

Xu, S., Zhang, Z., Jing, B., Gannon, P., Ding, J., Xu, F., Li, X. and Zhang, Y.* 2011. Transportin-SR is required for proper splicing of resistance genes and plant immunity.  PLoS Genetics, 7(6): e1002159.

Jing, B., Xu, S., Xu, M., Li, Y., Li, S., Ding, J. and Zhang, Y.* 2011. Brush and Spray: A high throughput systemic acquired resistance assay suitable for large-scale genetic screening. Plant Physiology, 157(3):973-80.

Zhang, Y., Xu, S., Ding, P., Wang, D., Cheng, Y., He, J., Gao, M., Xu, F., Li, Y., Zhu, Z., Li, X., and Zhang, Y.* 2010. Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors. PNAS (track II).107(42):18220-18225.

Zhang, Y., Yang, Y., Fang, B., Gannon, P., Ding, P., Li, X., and Zhang, Y.* 2010. snc2-1D activates receptor like protein-mediated immunity transduced through WRKY70. Plant Cell, 22(9):3153-3163.

Zhu, Z., Xu, F., Zhang, Y., Cheng, Y., Wiermer, M., Li, X., and Zhang, Y.* 2010. Arabidopsis Resistance protein SNC1 activates immune responses through association with a transcriptional co-repressor. PNAS (track II). 107(31):13960-13965.

Gao, M., Wang, X., Wang, D., Xu, F., Ding, X., Zhang, Z., Bi, D., Cheng, Y.T., Chen, S., Li, X., and Zhang, Y.* 2009. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host & Microbe 6:34-44.

Gao, M., Liu, J., Bi, D., Zhang, Z., Cheng, F., Chen, S., and Zhang, Y.* 2008. MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants. Cell Research 18:1190-1198. (Cover story)

Zhang, Y.*, Cheng, Y.T., Qu, N., Zhao, Q., Bi, D., and Li, X. 2006. Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs. Plant Journal 48: 647-656.

Zhang, Y.*, Tessaro, M., Lassner M., and Li, X. 2003. Knockout Analysis of Arabidopsis TGA2, TGA5 and TGA6 revealed their redundant and essential roles in systemic acquired resistance. Plant Cell 15: 2647-2653.