杨毅教授简介

杨毅博士，四川大学生命科学学院教授，博士研究生导师，四川省学术和技术带头人。曾担任四川大学“985工程”西南资源环境与灾害防治科技创新平台—生物资源与生态环境研究中心主任（2005-2015），生物资源与生态环境教育部重点实验室主任（2005-2018），四川省细胞生物学会理事长（2008-2016），中国细胞生物学会常务理事（2006-2012）。

联系方式：

电子邮件：yangyi528@scu.edu.cn；电话：028-85410957

学历简历：

1979.09.01-1983.07.30 云南大学生物系学习并获理学学士学位；

1980.09.01-1988.07.30 四川大学生物系学习并获理学硕士学位；

1999.05.01-2003.09.30 德国慕尼黑工业大学学习并获理学博士学位；

工作简历：

1983.09.01-1985.08.30 河北唐山华北煤炭医学院助教；

1988.09.01-1996.12.30 四川大学生物系助教、讲师、副教授；

1997.01.01-1999.04.30 德国慕尼黑大学植物研究所，访问学者

1999.05.01-2003.09.30 德国慕尼黑工业大学，科学合作者

2003.10.01-今 四川大学生命科学学院教授，博士生导师

科学研究：

主要的研究领域：

1. 植物抗逆的分子机理包括信号分子筛选、鉴定、基因功能和表达调控分析；

2. 微生物抗逆途径的分子机理分析；

   招生方向：遗传学、植物学、生物化学与分子生物学、植物生态学

   承担的主要科研项目：

3. 国家自然科学基金项目“AtARRE和AtTRE1泛素化修饰调控植物非生物胁迫应答的分子机制分析”批准号：31870240，项目经费：60万，项目主持人（2019-2022）

4. 国家自然科学基金项目“CARK磷酸化ABA受体PYL/PYR/RCAR的调控网络”批准号：31671455，项目经费：62万，项目主持人（2017-2020）

5. 973计划“生物固氮及相关抗逆模块的人工设计与系统优化”（2015-2019），课题编号2015CB755700，子课题负责人，210万

6. 973计划“抗逆元器件的构建和机理研究-微生物抗逆元器件在底盘植物中的功能重建与智能控制”（2013-2015），课题编号：2013CB733903，项目经费：100万，子课题负责人

7. 863计划(国家高技术研究发展计划)_重大项目“ 制革用酶研制与生物制革新工艺”2012-2015，批准号：2012AA022204，项目经费：926万，课题主持人

8. 国家自然科学基金项目“耐热基因BnTR1提高油菜脂肪酸不饱和度的作用机理分析”2012-2015，批准号：31171586，项目经费：75万，项目主持人

9. 国家转基因重大专项：耐热基因TT1功能验证及其在水稻中育种价值分析（2009-2010），批准号：2009ZX08009-080B，项目经费：157万，项目主持人

10. 国家自然科学基金项目“耐热基因TT1功能及表达调控分析”（2010-2012），批准号：30971557，项目经费：35万，项目主持人

11. 国家自然科学基金项目“谷氨酰转移核糖核酸（AtGluRS）及其相互作用蛋白质在脱落酸信号传导途径中的功能研究”（2007-2009），批准号：30671165，项目经费：30万，项目主持人

12. 国家自然科学基金项目“Fibrillin在拟南芥植物细胞内的功能以及在甘蓝型油菜中的表达研究”（2005-2007），批准号：30470927，项目经费：25万，项目主持人

    主要学术成果：

13. 利用ABI2为诱饵筛选并鉴定出脱落酸（ABA）信号传导途径中的新信号分子Fibrillin，通过揭示Fibrillin的积累介入了ABA所介导的PSII光保护的过程，从而在脱落酸应答途径、Fibrillin和光胁迫之间建立了一种全新的联系，并证明Fibrillin基因表达和其作用可能紧密地交织在脱落酸信号传导的过程中（Yang et al., PNAS 2006）。与德国Grill教授合作发现植物激素脱落酸细胞内受体 (Yang, Dissertation, 2003; Ma et al., Science 2009)，该项工作被称为是“Land Marker Paper”，被Science评选为2009年全球十大科技进展。

14. 解析了蛋白质激酶CARK1通过磷酸化ABA受体来调控ABA信号的分子机理(Cell Discovery, 2018; JEXBOT, 2019)以及E3泛素连接酶AtRAE1, RIFP1通过降解ABA受体进而参与ABA信号的传递(Plant, Cell & Environment, 2016, 2018)；阐明一个全新的UDP-糖基转移酶UGT71C5如何在植物体内催化脱落酸ABA(有活性)转化为ABA-GE(无活性)，从而达到植物体内ABA的内稳态平衡的分子机制(Plant Physiology, 2015)。

15. 发现一个与植物、微生物的热耐受性相关的未知基因BnTR1。将BnTR1转入在水稻、烟草、拟南芥、小麦、玉米和黑麦草中也发现能够增加植物的抗逆能力。同时，TR1也能够提高工业微生物如产苏氨酸棒状杆菌、产赖氨酸棒状杆菌和啤酒酵母等的耐热性能。因此，BnTR1具有重要的理论意义和巨大的实际应有价值。目前，以第一发明人身份申请了12项有关TR1的国家发明专利和2项国际PCT保护权。

    代表性文章：

16. Hsi-Hua Wang, Yao Qiu, Qin Yu, Qian Zhang, Xiaoyi Li, Jianmei Wang, Xufeng Li, Yang Zhang and Yi Yang*. Close arrangement of CARK3 and PMEIL affects ABA-mediated pollen sterility in Arabidopsis thaliana. 2020, Plant, Cell & Environment. DOI: 10.1111/pce.13871

17. Ruirui Yang, Tao Wang, Wensen Shi, Siyu Li, Zhibin Liu, Jianmei Wang, Yi Yang* Arabidopsis E3 Ubiquitin Ligase ATL61 Acts as a Positive Regulator in Abscisic Acid Signaling and Drought Response. 2020, BBRC DOI:10.1016/j.bbrc.2020.05.067

18. Yang Fang, Chengcheng Liu, Jiangyi Lin, Xufeng Li, Kambiz N. Alavian, Yi Yang*, Yulong Niu*. PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees. BMC Evolutionary Biology 2019, 19:219

19. Xibing Xu, Tao Wang, Yulong Niu, Ke Liang, Yi Yang* (2019). The ubiquitin-like modification by ThiS and ThiF in Escherichia coli. International Journal of Biological Macromolecules 2019, 141:351-7

20. Xiaoyi Li, Xiangge Kong, Qi Huang, Qian Zhang, Hu Ge, Liang Zhang, Gaoming Li, Lu Peng, Zhibin Liu, Jianmei Wang, Xufeng Li, Yi Yang*. CARK1 phosphorylates subfamily III members of ABA receptors. Journal of Experimental Botany 2019, 70(2): 517-28.

21. Yanlin Ma, Jing Cao, Jiahan He, Qiaoqiao Chen, Xufeng Li and Yi Yang*. Molecular Mechanism for the Regulation of ABA Homeostasis During Plant Development and Stress Responses. Int. J. Mol. Sci. 2018, 19, 3643

22. Xiaoyi Li, Gaoming Li, Ying Li, Xiangge Kong, Liang Zhang, Jianmei Wang, Xufeng Li and Yi Yang*. ABA receptors subfamily III enhances abscisic acid sensitivity and improves drought tolerance of Arabidopsis. Int. J. Mol. Sci. 2018, 19(7), 1938

23. Hu Ge, Xiaoyi Li, Shisi Chen, Mengru Zhang, Zhibin Liu, Jianmei Wang, Xufeng Li, Yi Yang*. The expression of CARK1 or RCAR11 driven by synthetic promoters increases drought tolerance in Arabidopsis thaliana. Int. J. Mol. Sci. 2018, 19(7), 1945

24. Liang Zhang, Xiaoyi Li, Dekuan Li, Yuna Sun, Ying Li, Qin Luo, Zhibin Liu, Jianmei Wang, Xufeng Li, Hong Zhang, Zhiyong Lou* and Yi Yang*. CARK1 mediates ABA signaling by phosphorylation of ABA receptors. Cell Discovery 2018, 4:30

25. Boya Wang, Cuze Li, Xiangge Kong, Ying Li, Zhibin Liu, Jianmei Wang, Xufeng Li, Yi Yang*. AtARRE, an E3 ubiquitin ligase, negatively regulates ABA signaling in Arabidopsis thaliana. Plant Cell Reports 2018, 37(9):1269-78

26. Xibing Xu, Ke Liang, Yulong Niu, Yan Shen, Xuedong Wan, Haiyan Li, Yi Yang*. BAH1 an E3 Ligase from Arabidopsis thaliana Stabilizes Heat Shock Factor σ³² of Escherichia coli by Interacting with DnaK/DnaJ Chaperone Team. Current Microbiology. 2018, 75(4)

27. Cun Chen, Chun-Hong Liu, Jing Cai, Wei Zhang, Wei-Liang Qi, Zheng Wang, Zhi-Bin Liu, Yi Yang*. Broad-spectrum antimicrobial activity, chemical composition and mechanism of action of garlic (Allium sativum) extracts. Food Control 2018, 86:117-25.

28. Dekuan Li , Liang Zhang , Xiaoyi Li , Xiangge Kong, Xiaoyu Wang, Ying Li, Zhibin Liu, Jianmei Wang, Xufeng Li, Yi Yang*. AtRAE1 is involved in degradation of ABA receptor RCAR1 and negatively regulates ABA signaling in Arabidopsis. Plant, Cell & Environment. 2018, 41:231-44.

29. Yulong Niu^§, Xibing Xu^§, Chengcheng Liu, Tao Wang, Ke Liang, Jianmei Wang, Zhibin Liu, Xufeng Li, Yi Yang*. A novel plant E3 ligase stabilizes Escherichia coli heat shock factor σ³². Scientific Reports 2017, 7(e) 4045

30. Xibing Xu, Yulong Niu, Ke Liang, Guomin Shen, Qing Cao, Yi Yang∗. Analysis of pupylation of Streptomyces hygroscopicus 5008 in vitro. BBRC, 2016. 474(1): 126-30.

31. Tao Wang, Xiangjun Chen, Jun Han, Sichun Ma, Jianmei Wang, Xufeng Li, Hui Zhang, Zhibin Liu∗, Yi Yang∗. Effects of the cofactor binding sites on the activities of secondary alcohol dehydrogenase (SADH). International Journal of Biological Macromolecules, 2016, 88:385–91

32. Ying Li, Zhibin Liu, Jianmei Wang, Xufeng Li and Yi Yang*. The Arabidopsis Kelch repeat F-box E3 ligase ARKP1 plays a positive role for the regulation of abscisic acid signaling. Plant Molecular Biology Reporter. 2016, 34(3), 582-91.

33. Ying Li, Liang Zhang, Dekuan Li, Zhibin Liu, Jianmei Wang, Xufeng Li and Yi Yang*. The Arabidopsis F-box E3 ligase RIFP1 plays a negative role in abscisic acid signaling by facilitating ABA receptor RCAR3 degradation. Plant, Cell & Environment. 2016, 39(3), 571-582. DOI: 10.1111/pce.12639

34. Liang Yang, Qiaohong Liu, Zhibin Liu, Hao Yang, Jianmei Wang, Xufeng Li and Yi Yang*. Arabidopsis C3HC4-RING finger E3 ubiquitin ligase AtAIRP4 positively regulates stress-responsive abscisic acid signaling. Journal of Integrative Plant Biology, 2016, 58(1):67-80.

35. Xibing Xu, Yulong Niu, Ke Liang, Jianmei Wang, Xufeng Li, Yi Yang^＊. Heat Shock Transcription Factor δ³² is targeted for degradation via an ubiquitin-like protein ThiS in Escherichia coli. BBRC. 2015 459(2):240-5.

36. Zhen Liu, Jin-Ping Yan, De-Kuan Li, Qin Luo, Qiujie Yan, Zhi-Bin Liu, Li-Ming Ye, Jian-Mei Wang, Xu-Feng Li, Yi Yang^＊. UGT71C5, a major glucosyltransferase mediates ABA homeostasis in Arabidopsis thaliana. Plant Physiology. 2015, 167(4): 1659-70.

37. Dekuan Li, Ying Li, Liang Zhang, Xiaoyu Wang, Zhe Zhao, Zhiwen Tao, Jianmei Wang, Jin Wang, Min Lin, Xufeng Li and Yi Yang^＊. Arabidopsis ABA Receptor RCAR1/PYL9 Interacts with an R2R3-Type MYB Transcription Factor, AtMYB44. Int. J. Mol. Sci. 2014, 15, 8473-90.

38. Fengxi Yang, Zhibin Liu, Jianmei Wang, Xufeng Li, Yi Yang^＊. An auxin-responsive endogenous peptide regulates root development in Arabidopsis. Journal of Integrative Plant Biology, 2014, 56:635-47.

39. Dekuan Li, Xiaoyu Wang, Dezhi Yuan, Liang Zhang, Xin Jiang, Zhiwen Tao, Ying Li, Jianmei Wang,Xufeng Li, Yi Yang^＊. Over-expression of ArathEULS3 confers ABA sensitivity and drought tolerance in Arabidopsis. Plant Cell, Tissue and Organ Culture, 2014, 117, 3:431-42.

40. Zhi-Bin Liu, Jian-Mei Wang, Feng-Xi Yang, Liang Yang, Yu-Fei Yue, Jun-Bei Xiang, Mei Gao, Fang-Jian Xiong, Dong Lv, Xian-Jun Wu, Ning Liu, Xun Zhang, Xu-Feng Li and Yi Yang^＊. A novel membrane-bound E3 ubiquitin ligase enhances the thermal resistance in plants. Plant Biotechnology Journal, 2014, 12(1):93-104.

41. Qu Wubin, Yang Zhou, Yanchun Zhang, Yiming Lu, Xiaolei Wang, Dongsheng Zhao, Yi Yang and Chenggang Zhang, MFEprimer-2.0: a fast thermodynamics- based program for checking PCR primer specificity. Nucleic Acids Research, 2012, 40(W1), pp W205-W208.

42. Yang Zhou, Wubin Qu, Yiming Lu, Yanchun Zhang, Xiaolei Wang, Dongsheng Zhao, Yi Yang^＊ and Chenggang Zhang. VizPrimer: a web server for visualised PCR primer design based on known gene structure. 2011, Bioinformatics 27(24): 3432-4.

43. Jinping Yan, Han He, Shibo Tong, Wanrong Zhang, Jianmei Wang, Xufeng Li and Yi Yang^＊. Voltage-Dependent Anion Channel 2 of Arabidopsis Thaliana (AtVDAC2) Is Involved In ABA-Mediated Early Seedling Development. Int. J. Mol. Sci. 2009, 10(6):2476-86.

44. Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, Grill E. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009, 324 (5930):1064-8.

45. Zhongyu Liu, Xufeng Li, Xianping Ding, Yi Yang. In Silico and Experimental Studies of Concanavalin A: Insights into Its Antiproliferative Activity and Apoptotic Mechanism. Appl Biochem Biotechnol. 2010，9:134-45.

46. Qu Wubin, Shen Zhiyong, Zhao Dongsheng, Yang Yi^＊ and Zhang Chenggang. MFEprimer: Multiple factor evaluation of the specificity of PCR primers, Bioinformatics, 2009, 25(2):276-8.

47. Yang, Y., Sulpice, R., Himmelbach, A., Chrismann, A., Mainhard, M., and Grill, E. Fibrillin expression is regulated by abscisic acid response regulators and is involved in abscisic acid-mediated photoprotection. Proc. Natl. Acad. Sci. USA., 2006, 103:6061-6.

48. Himmelbach, A., Yang, Y., Grill, E. Relay and control of abscisic acid signaling. Current Opinion in Plant Biology, 2003, 6:470-9.

    会议

49. International Symposium on Application of Functional Genomics and Genetics to Modern Agriculture (AFGGMA 2014, Chongqing) , 2014.6.12-17, 大会报告，题目：A novel membrane-bound E3 ubiquitin ligase enhances the thermal resistance in Plants

50. 12th International Conference on the Frontiers of Plant Biology: plant hormone mechanism and development (Chengdu, China)，2015.4.10-14，大会报告，题目：A brief introduction of current progress of ABA signaling

51. 国际固氮大会，成都，2014.10，大会组织者

52. 转基因成果交流会，成都，2018.5. 大会组织者