
雷昌伟
雷昌伟,博士,博士后,副研究员,主要从事人兽共患病原菌防控及其耐药机制研究,发现多个能介导细菌多重耐药的新型可移动遗传元件。以第1/并1或通讯作者在J Antimicrob Chemother、Antimicrob Agents Chemother、ACS Sens、Front Microbiol、Int J Food Microbiol、Vet Microbiol等杂志上发表SCI 论文20余篇,参与申请国家发明专利8项,参与制定四川省地方标准3项,获2018年四川省科技进步一等奖(排名第5)。担任四川省畜牧兽医学会第十届理事会理事(2017-2022)。主讲本科生课程《专业英语导读与写作》、《动物健康与产品安全》等。
Email:
leichangwei@scu.edu.cn;leichangwei@126.com
学习及工作经历
2019.07-至 今:四川大学 副研究员
2016.07-2019.06:四川大学 助理研究员/博士后
2012.09-2016.06:四川大学 微生物学/博士
2008.09-2012.06:四川大学 生物科学基地班/学士
主要科研项目
国家自然科学基金青年基金项目,32100147,畜禽源奇异变形杆菌中新型多重耐药基因岛PmGRI1及其水平转移机制研究,2022.01-2024.12,主持;
四川省“十四五”川猪重大科技专项“川猪重大疫病防控新技术新产品创制”课题“减抗禁抗背景下猪细菌病的溯源及新产品创制”,2021.07-2026.06,课题负责人;
国家重点研发计划子课题,2018YFD0500503-4,家禽养殖和屠宰过程中沙门菌的流行和传播规律研究,2018.06-2020.12,主持;
四川省国际合作项目,2018HH0027,畜禽养殖环境中耐药基因传播风险研究,2018.01-2020.12,主持;
国家自然科学基金重点项目,31830098,可移动遗传元件(IncA/C质粒、ICEs、Tn7-like元件) 演化与沙门氏菌、大肠杆菌、肺炎克雷伯多重耐药菌形成和传播机制,2019.01-2023.12,主研。
获奖情况
生命科学学院优秀党务工作者(2021);
第五届全国大学生生命科学竞赛一等奖指导老师(2020);
四川大学本科优秀毕业论文一等奖指导老师(2019);
四川省科技进步一等奖(2018,排名第5)。
代表性论文
Lei CW, Chen X, Liu SY, Li TY, Chen Y, Wang HN*. Clonal spread and horizontal transfer mediate dissemination of phenicol-oxazolidinone-tetracycline resistance gene poxtA in enterococci isolates from a swine farm in China. Vet Microbiol. 2021; 262:109219.
Wang YT1, Lei CW1*, Liu SY, Chen X, Gao YF, Zhang Y, Tang Y, Zhang A, Yang X, Wang HN*. Tracking Salmonella enterica by whole genome sequencing of isolates recovered from broiler chickens in a poultry production system. Int J Food Microbiol. 2021; 350:109246.
Xia X, Ma B, Zhang T, Lu Y, Khan MR, Hu Y, Lei C*, Deng S, He Q*, He G, Zhang K, Deng R*. G-Quadruplex-Probing CRISPR-Cas12 Assay for Label-Free Analysis of Foodborne Pathogens and Their Colonization In Vivo. ACS Sens. 2021; 6(9):3295-3302.
Lei CW, Zhang Y, Kang ZZ, Kong LH, Tang YZ, Zhang AY, Yang X, Wang HN*. Vertical transmission of Salmonella Enteritidis with heterogeneous antimicrobial resistance from breeding chickens to commercial chickens in China. Vet Microbiol. 2020; 240:108538.
Lei CW, Yao TG, Yan J, Li BY, Wang XC, Zhang Y, Gao YF, Wang HN*. Identification of Proteus genomic island 2 variants in two clonal Proteus mirabilis isolates with coexistence of a novel genomic resistance island PmGRI1. J Antimicrob Chemother. 2020; 75(9):2503-2507.
Lei CW, Zhang Y, Wang YT, Wang HN*. Detection of Mobile Colistin Resistance Gene mcr-10.1 in a Conjugative Plasmid from Enterobacter roggenkampii of Chicken Origin in China. Antimicrob Agents Chemother. 2020; 64(10):e01191-20.
Yao TG, Li BY, Luan RD, Wang HN, Lei CW*. Whole genome sequence of Enterococcus gallinarum EG81, a porcine strain harbouring the oxazolidinone-phenicol resistance gene optrA with chromosomal and plasmid location. J Glob Antimicrob Resist. 2020; 22:598-600.
Lei CW, Kang ZZ, Wu SK, Chen YP, Kong LH, Wang HN*. Detection of the phenicol-oxazolidinone-tetracycline resistance gene poxtA in Enterococcus faecium and Enterococcus faecalis of food-producing animal origin in China. J Antimicrob Chemother. 2019; 74(8):2459-2461.
Lei CW1, Chen YP1, Kang ZZ, Kong LH, Wang HN*. Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying cfr, blaCTX-M-65, fosA3, and aac(6')-Ib-cr in Proteus mirabilis. Antimicrob Agents Chemother. 2018; 62(9):e00849-18.
Lei CW, Chen YP, Kong LH, Zeng JX, Wang YX, Zhang AY, Wang HN*. PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis. Antimicrob Agents Chemother. 2018; 62(5):e00019-18.
谢鑫,张踞林,王红宁,雷昌伟*.芽孢杆菌中天然脂肽类抗生素的合成及作用机制研究进展[J].中国抗生素杂志,2021,46(05):362-370.
李博洋,姚天歌,栾仁栋,王红宁,雷昌伟*.奇异变形杆菌中基因岛介导的多重耐药传播研究进展[J].微生物学通报,2021,48(03):916-923.