张安云，教授，博士生导师

招生专业：生物学 （博士、硕士） 招生方向：1）微生物学 2）生物信息学 E-mail：zhanganyun[at]scu.edu.cn

1、个人简介

四川大学生命科学学院教授，博士生导师。主要从事畜禽病原细菌及其耐药性产生机理、传播途径和防控措施研究。四川省学术和技术带头人后备人选，美国华盛顿州立大学和俄亥俄州立大学访问学者，四川省畜牧兽医学会理事，四川省微生物学学会理事。先后主持“十三五”国家重点研发计划课题，国家自然科学青年基金、面上项目等项目8项。已发表SCI论文56篇，其中以第一作者或通讯作者在WATER RES（IF: 9.13 Nature index），ENVIRON POLLUT (IF: 6.792)，SCI TOTAL ENVIRON (IF:6.551) 等权威SCI杂志上发表25篇。作为主要完成人获国家科技进步二等奖1项(排名第4)，四川省科技进步一等奖1项(排名第3)。担任国家自然基金委函评专家，国家动物疫病净化评估专家，WATER RES, J HAZARD MATER, J ANTIMICROB CHEMOTH等10余个SCI杂志审稿人。

2、研究方向

1）畜禽重要病原菌在养殖过程和食品生产链中传播和分子溯源研究；

2）耐药病原菌中新型耐药基因发现及可移动转移元件（质粒，噬菌体，整合性接合元件，基因岛等）介导的耐药基因在细菌间传播机理和调控因子研究；

3）抗生素污染环境（养殖环境，畜禽粪便，水体等）中病原菌、耐药基因传播风险评估，新型抗生素减量化技术和产品开发。

3、承担科研项目

1）国家重点研发计划课题，种禽场沙门氏菌病综合防控技术集成与示范研究，主持。

2）国家自然科学基金面上项目，多重耐药红斑猪丹毒丝菌中新型整合性接合元件(ICEs)及其传播机理研究，主持。

3）国家“973”项目子课题，耐药病原菌新药靶标和先导化合物的筛选与确证，主持。

4）国家自然科学青年基金项目，禽沙门氏菌I 型整合子与PMQR基因流行特征及共传播机理，主持。

5）四川省科技厅中央引导地方科技发展专项资金项目，规模化畜禽养殖场病原菌溯源及抗生素减量化技术研究，主持。

6）四川省科技厅应用基础项目，畜禽粪污处理过程中质粒介导的抗生素耐药基因变化规律及传播风险评估研究，主持。

7）四川省科技厅应用基础项目，规模化猪场猪丹毒丝菌耐药机理，毒力变化及疫苗侯选株筛选研究，主持。

8）四川大学优秀青年学者基金“动物病原菌及其耐药性传播机理”，主持。

4、代表性论文（*通讯作者，^# 并列一作）

1. Gu J, Xie X, Liu J, Shui J, Zhang H, Feng G, Liu Xiao, Li L, Lan W, Jin Q, Li R, Peng L, Lei C,  Zhang A*. 2020. Prevalence and transmission of antimicrobial-resistant Staphylococci and Enterococci from shared bicycles in Chengdu, China. Science of The Total Environment, 738, 139735. https://doi.org/10.1016/j.scitotenv.2020.139735

2. Li P, Zhang X, Xie X, Tu Z, Gu J, Zhang A*. 2020. Characterization and whole-genome sequencing of broad-host-range Salmonella-specific bacteriophages for bio-control, Microbial Pathogenesis, 143：104119. https://doi.org/10.1016/j.micpath.2020.104119

3. Gu J, Li Y, Xu C, Xie X, Li P, Ma G, Lei C, Liu J, Zhang A*. 2020. Genome sequence of a multidrug-resistant Erysipelothrix rhusiopathiae ZJ carrying several acquired resistance genes. Journal of Global Antimicrobial Resistance. 21:13-15. https://doi.org/10.1016/j.jgar.2020.02.017

4. Deng W^#, Zhang A^#, Chen S, He X, Jin L, Yu X, Yang S, Li B, Fan L, Ji L, Pan X, Zou L*. 2020. Heavy metals, antibiotics and nutrients affect the bacterial community and resistance genes in chicken manure composting and fertilized soil. Journal of Environmental Management 257:109980. https://doi.org/10.1016/j.jenvman.2019.109980

5. Zhang A, Call DR, Besser TE, Liu J, Jones L, Wang H, Davis MA*. 2019. β-lactam resistance genes in bacteriophage and bacterial DNA from wastewater, river water, and irrigation water in Washington State. Water Research. 161:335-340. https://doi.org/10.1016/j.watres.2019.06.026

6. Liu D, Yang Y, Gu J, Tuo H, Li P, Xie X, Ma G-x, Liu J, Zhang A*. 2019. The Yersinia high-pathogenicity island (HPI) carried by a new integrative and conjugative element (ICE) in a multidrug-resistant and hypervirulent Klebsiella pneumoniae strain SCsl1. Veterinary Microbiology:108481. https://doi.org/10.1016/j.vetmic.2019.108481

7. Liu J, Zhao Z, Avillan JJ, Call DR, Davis M, Sischo WM, Zhang A*. 2019. Dairy farm soil presents distinct microbiota and varied prevalence of antibiotic resistance across housing areas. Environmental Pollution 254:113058. https://doi.org/10.1016/j.envpol.2019.113058

8. Yang Y, Xie X, Tang M, Liu J, Tuo H, Gu J, Tang Y, Lei C, Wang H, Zhang A*. 2019. Exploring the profile of antimicrobial resistance genes harboring by bacteriophage in chicken feces. Science of The Total Environment: 134446. https://doi.org/10.1016/j.scitotenv.2019.134446

9. Li P, Liu D, Zhang X, Tuo H, Lei C, Xie X, Gu J, Zhang A*. 2019. Characterization of Plasmid-Mediated Quinolone Resistance in Gram-Negative Bacterial Strains from Animals and Humans in China. Microbial Drug Resistance. 25(7): 1050-1056. https://doi.org/10.1089/mdr.2018.0405.

10. Yang Y, Shi W, Lu S-Y, Liu J, Liang H, Yang Y, Duan G, Li Y, Wang H, Zhang A*. 2018. Prevalence of antibiotic resistance genes in bacteriophage DNA fraction from Funan River water in Sichuan, China. Science of The Total Environment 626:835-841. https://doi.org/10.1016/j.scitotenv.2018.01.148

11. Liu J, Yang Y, Li Y, Liu D, Tuo H, Wang H, Call DR, Davis M, Zhang A*. 2018. Isolation of an IncP-1 plasmid harbouring mcr-1 from a chicken isolate of Citrobacter braakii in China. International journal of antimicrobial agents 51:936-940. https://doi.org/10.1016/j.ijantimicag.2017.12.030

12. Zhang A, Li Y, Guan Z, Tuo H, Liu D, Yang Y, Xu C, Lei C, Wang H*. 2018. Characterization of Resistance Patterns and Detection of Apramycin Resistance Genes in Escherichia coli Isolated from Chicken Feces and Houseflies after Apramycin Administration. Frontiers in microbiology 9:328. doi: 10.3389/fmicb.2018.00328

13. Tuo H, Yang Y, Tao X, Liu D, Li Y, Xie X, Li P, Gu J, Kong L, Xiang R, Lei C, Wang H, Zhang A*. 2018. The prevalence of colistin resistant strains and antibiotic resistance gene profiles in Funan River, China. Frontiers in microbiology 9. doi: 10.3389/fmicb.2018.03094

14. Wang Y^#, Zhang A^#, Yang Y, Lei C, Jiang W, Liu B, Shi H, Kong L, Cheng G, Zhang X. 2017. Emergence of Salmonella enterica serovar Indiana and California isolates with concurrent resistance to cefotaxime, amikacin and ciprofloxacin from chickens in China. International journal of food microbiology 262:23-30. https://doi.org/10.1016/j.ijfoodmicro.2017.09.012

15. Long M, Yu H, Chen L, Wu G, Zhao S, Deng W, Chen S, Zhou K, Liu S, He L, Ao X, Yan Y, Ma M, Wang H, Davis MA, Jones L, Li B, Zhang A*, Zou L*. 2017. Recovery of Salmonella isolated from eggs and the commercial layer farms. Gut pathogens 9:74. doi: 10.1186/s13099-017-0223-8

16. Yang Y-X, Yang Y-Q, Lei C-W, Liu B-H, Jiang W, Wang H-N, Gazitúa MC, Zhang A-Y*. 2017. Characterization of pHeBE7, an IncFII-type virulence-resistance plasmid carrying blaCTX-M-98b, blaTEM-1, and rmtB genes, detected in Escherichia coli from a chicken isolate in China. Plasmid 92:37-42. https://doi.org/10.1016/j.plasmid.2017.07.001

17. Zhang A, He X, Meng Y, Guo L, Long M, Yu H, Li B, Fan L, Liu S, Wang H*. 2016. Antibiotic and disinfectant resistance of Escherichia coli isolated from retail meats in Sichuan, China. Microbial Drug Resistance 22:80-87. DOI ：10.1089/mdr.2015.0061

18. Yang Y-Q^#, Zhang A-Y^#, Ma S-Z, Kong L-H, Li Y-X, Liu J-X, Davis MA, Guo X-Y, Liu B-H, Lei C-W. 2016. Co-occurrence of mcr-1 and ESBL on a single plasmid in Salmonella enterica. Journal of Antimicrobial Chemotherapy 71:2336-2338. DOI ：10.1093/jac/dkw243

19. Zhang A, Yang Y, Wang H*, Lei C, Xu C, Guan Z, Liu B, Huang X, Peng L. 2015. Prevalence of sulfonamide and Florfenicol resistance genes in Escherichia Coli isolated from yaks (Bos Grunniens) and herdsmen in the Tibetan pasture. Journal of wildlife diseases 51:626-633. DOI ：10.7589/2014-09-234

20. Zhang A, Xu C, Wang H*, Lei C, Liu B, Guan Z, Yang C, Yang Y, Peng L. 2015. Presence and new genetic environment of pleuromutilin–lincosamide–streptogramin A resistance gene lsa (E) in Erysipelothrix rhusiopathiae of swine origin. Veterinary microbiology 177:162-167. https://doi.org/10.1016/j.vetmic.2015.02.014

     

21. 主要获奖情况

    2020 第六届“互联网+”大学生创新创业大赛，校级金奖 指导教师

    2018 四川省科学技术进步一等奖，蛋鸡细菌病防控系统创新与安全蛋品生产关键技术（排名第3）

    2016 四川大学大学生课外科技实践活动优秀指导教师

    2015 四川大学优秀青年学者基金获得者

    2013、2015四川大学年度本科课堂教学质量优秀奖

    2012 国家科学技术进步二等奖，猪鸡病原细菌耐药性研究及其在安全高效新兽药研制中的应用（排名第4）

    2011 四川大学优秀青年教师奖