李中瀚
教授， 博士生导师
联系方式：
Email: Zhonghan.Li@scu.edu.cn
地址：四川省成都市武侯区望江路29号,
四川大学生命科学学院B610
欢迎真正对基础生物学研究感兴趣的学生
和博士后联系！
We live for science. We keep pushing.
个人简介:
长期从事间质谱系命运重编程、矿化组织器官发育与再生调控研究，研究成果在Cell Chemical Biology (2027), Science Advances (2026, 2025, 2020), Nature Communications (2025, 2012), EMBO J (2011), PNAS (2020, 2014), Cell Reports (2022), Advanced Science (2024, 2023), Genome Biology (2013), Stem Cell Reports (2024), PLoS Pathogens (2024), Accounts in Chemical Research (2012), Nature Reviews Drug Discovery(2014) 等国际著名学术期刊上发表，他引超过5000次。当选四川省学术和技术带头人，担任中国生化与分子生物学学会常务理事，四川省生物化学与分子生物学学会秘书长等。研究成果获评中国2020年度重要医学进展和2023年中华医学科技奖二等奖等。获得国家发明专利4项，全部完成技术转化，技术授权两家上市企业，孵化一家国家高新技术企业，2026年同时获批CDE和FDA临床批件。相关研究也牵头获得“合成生物学”国家重点研发计划、国家自然基金委区域联合基金重点项目、面上项目、四川省重大科技专项和西藏自治区重点研发计划等资助。
学习及工作经历：
2001- 2005 复旦大学，生命科学，本科
2005- 2012 麻省大学医学院，生化和分子制药系，博士
2012- 2014 美国辉瑞制药，药物安全研发部，博士后
2014- 2015 美国辉瑞制药，药物安全研发部，Senior Scientist
2015- 至今 四川大学生命科学学院教授
2017- 至今 兼任生命科学学院副院长
科学研究：
1. 以大规模正向遗传筛选，研究间质谱系干细胞分化及其调控机制；
2. 解析组织器官发育时空规律，基于合成生物学，开发组织再生新技术；
3. 间质谱系干细胞的命运重编程与衰老调控。
代表性论文：
1. Huang X, Zhong Y, Wang K, Li Y, Du L, Chen H, Xiong J, Bao H, Wang C, Cai H, Yang H*, Tian W*, Qi S*, and Li Z*. Phase-separated SOX5 as a molecular switch for human cranial neural crest fate commitment. Cell Chemical Biology. (2027) 34, 1–18.
2. Zhang Z, Xu Z, Hu H, Li Y, Jin Y, Zhong Yi, Zhang Y, Yin Y, Chen J*, Duan Y*, Yang H*, and Li Z*. DLX2 acts as a pioneer factor and drives Msx1+ ectomesenchyme formation from embryonic stem cells. Science Advances. (2026) 12(3):eaea0685.
3. Shan C, Wang W, Lu H, Wang K, Wang T, Zhang Z, Li M, Chen Y, Xiao ZX, Cai H, Tian W, Zhang Y*, Li B*, Li Z*. A spatially organized Cd24a+/Pax9+ stem cell core governs postnatal tooth establishment. Science Advances. (2025) 11(23):eadu5653.
4. Xiong J, Ma R, Xie K, Shan C, Chen H, Wang Y, Liao Y, Deng Y, Ye G, Wang Y, Zhu Q, Zhang Y, Cai H, Guo W, Yin Y*, Li Z*. Recapitulation of human endochondral ossification by SOX9+ sclerotomal progenitors. Nature Communications. (2025) 16(1):2781.
5. Zhang Z, Hu H, Xu Z, Chen H, Xie K, Wang K, Wang Y, Zhu Q, Yin Y, Cai H, Zhang Y*, Li Z*. A chemically defined culture for tooth reconstitution. Advanced Science (2025) 12(3):e2404345.
6. Hu H, Zhao Y, Shan C, Fu H, Cai J, Li Z*. Derivation of dental epithelial-like cells from murine embryonic stem cells for tooth regeneration. Stem Cells. (2024) sxae052.
7. Wang C, Liu Y, Xiong J, Xie K, Wang T, Hu Y, Fu H, Zhang B, Huang X, Bao H, Cai H, Dong B*, Li Z*. Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction. PLoS Pathog. (2024) 20(7):e1012344.
8. Liao Y, Kang F, Xiong J, Xie K, Li M, Yu L, Wang Y, Chen H, Ye G, Yin Y, Guo W, Cai H, Zhu Q*, Li Z*. MSX1+PDGFRAlow limb mesenchyme-like cells as an efficient stem cell source for human cartilage regeneration. Stem Cell Reports. (2024) 19(3):399-413.
9. Meng TG*, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH*, Wang ZB*, Wong CL*, Li Z*, Sun QY*. NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Advanced Science (2023) e2301940.
10. Hu H, Duan Y, Wang K, Fu H, Liao Y, Wang T, Zhang Z, Kang F, Zhang B, Zhang H, Huo F, Yin Y, Chen G, Hu H, Cai H*, Tian W*, Li Z*. Dental niche cells directly contribute to tooth reconstitution and morphogenesis.Cell Reports (2022) 41(10):111737.
11. Zhang Y, Li Z*. RNA binding proteins: Linking mechanotransduction and tumor metastasis. Cancer Lett (2021) 496:30-40.
12. Yin Y, Cao S, Fu H, Fan X, Xiong J, Huang Q, Liu Y, Xie K, Meng TG, Liu Y, Tang D, Yang T, Dong B, Qi S, Nie L, Zhang H, Hu H, Xu W, Li F, Dai L, Sun QY, and Li Z*. A non-canonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis. Proc Natl Acad Sci USA (2020) 117(36):22237-22248.
13. Chen H, Fu H, Wu X, Duan Y, Zhang S, Hu H, Liao Y, Wang T, Yang Y, Chen G*, Li Z* and Tian W*. Regeneration of pulpo-dentinal-like complex by a group of unique multipotent CD24a positive stem cells. Science Advances (2020) 6(15):eaay1514.
14. Zheng Z, Hu H, Tong Y, Hu Z, Cao S, Shan C, Lin W, Yin Y and Li Z*. MiR-27b Regulates Podocyte Survival Through Targeting Adenosine Receptor 2B in Podocytes From Non-human Primate. Cell Death Dis (2018) 9(11):1133.
15. Li Z, Rana TM. Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol.(2014) 11:979-85.
16. Li Z, Rana TM. Therapeutic Targeting of MicroRNAs: Current Status and Future Challenges. Nat Rev Drug Discov. (2014). 13:622-38.
17. Li Z (co-first), Dang J, Rana TM. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA(2014). 20:1900-15.
18. Li Z (co-first), Chao TC, Chang K, Lin N, Burns JC, Rana TM*. The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl Acad Sci USA. (2014). 111:1002-7.
19. Henzler CM, Li Z (co-first), Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM*, Kosik KS*. Staged miRNA re-regulation patterns during reprogramming. Genome Biology. (2013). 14:R149.
20. Li Z, Rana,TM*. A Kinase library screen identifies small molecule activators of iPS cell Reprogramming. Nature Communcations. (2012) 3:1085.
21. Li Z, Rana, TM*. Molecular Mechanisms of RNA-triggered Gene Silencing Machineries. Accounts Chem Res. (2012) 45:1122-31.
22. Li Z, Yang,CS., Nakashima, K., Rana, TM*. Small RNA-mediated regulation of iPS cell Generation. EMBO J (2011) 30:823-34.
