刘科，博士，教授，博士生导师
电子邮件：kliu@scu.edu.cn
学位简历和工作简历
1991.9-1995.6，四川大学生物系生物化学专业学士
1995.9-1998.6，四川大学生物系生物化学专业硕士
1998.9-2001.6，中国科学院化学研究所化学博士
2001.10-2005.1，美国肯塔基大学细胞与分子生物化学系博士后
2010.2-2012.9，美国塔夫茨大学营养与衰老研究中心博士后
2005.7-四川大学生命科学学院教授
研究方向:
1.氧化胁迫对机体的破坏以及机体的防御和应答，衰老过程中蛋白质的损伤和周转代谢以及相关信号通路。
2.光合作用光化学反应及活性氧自由基的产生与调控。
3.自由基生物技术在环保、健康和美容领域的应用。
研究内容:
健康长寿是人类的美好愿望。我们通过对真核模式生物酿酒酵母以及动物细胞和动物模型寿命调控机理的研究，尝试阐明调控动物和人体寿命的分子机制。我们主要研究泛素系统在衰老及衰老相关疾病中对细胞内蛋白周转代谢的调控作用；细胞内活性氧自由基的产生和对细胞寿命的调控；营养和胁迫条件对细胞寿命的影响以及相关蛋白激酶参与的信号传导通路。我们同时也尽力促进科学研究在社会生产中的应用，促进相关领域的创业创新。我们非常欢迎对我们研究方向感兴趣的本科生和硕士、博士研究生加入我们，同时也热切期盼与相关专家学者开展学术交流。
主要发表文章：
1. Qie, B., Lyu, Z., Lyu, L., Liu, J., Gao, X., Liu, Y., Duan, W., Zhang, N., Du, L., and Liu, K. (2015) Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox biology 5, 290-300
2.Liu, K. *, Lyu, L., Chin, D., Gao, J., Sun, X., Shang, F., Caceres, A., Chang, M. L., Rowan, S., Peng, J., Mathias, R., Kasahara, H., Jiang, S., and Taylor, A*. (2015) Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract.Proceedings of the National Academy of Sciences of the United States of America112, 1071-1076
3. Shang, F., Wilmarth, P. A., Chang, M. L.,Liu, K., David, L. L., Caceres, M. A., Wawrousek, E., and Taylor, A. (2014) Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin.Journal of proteome research13, 1177-1189
4. Liu, J., Lu, L., Qie, B.-B., andLiu, K.*(2014) Regulation of The Phosphorylation of Yeast Protein Kinase Sch9 Under Environmental Changes and During Chronological Aging.Progress in Biochemistry and Biophysics41, 192-201
5. Du, L., Miao, X., Gao, Y., Jia, H.,Liu, K.*, and Liu, Y.* (2014) The protective effects of Trolox-loaded chitosan nanoparticles against hypoxia-mediated cell apoptosis.Nanomedicine : nanotechnology, biology, and medicine10, 1411-1420
6. Liu, J., Huang, X., Withers, B. R., Blalock, E.,Liu, K.*, and Dickson, R. C.* (2013) Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan.Aging Cell12, 833-841
7. Lin, J., Yu, Y., Shigdar, S., Fang, D. Z., Du, J. R., Wei, M. Q., Danks, A.,Liu, K., and Duan, W. (2012) Enhanced antitumor efficacy and reduced systemic toxicity of sulfatide-containing nanoliposomal doxorubicin in a xenograft model of colorectal cancer.PloS one7, e49277
8. Du, L., Miao, X., Jia, H., Gao, Y.,Liu, K.*, Zhang, X., and Liu, Y.* (2012) Detection of nitric oxide in macrophage cells for the assessment of the cytotoxicity of gold nanoparticles.Talanta101, 11-16
9.贺曾,杜立波,姜玉岗,陈良兵,王广清,田秋,刘科*,杜林方, and刘扬*. (2010)内源性超氧阴离子自由基介导的莱茵衣藻光系统Ⅱ蛋白组分损伤.生物物理学报v.26, 301-308
10.苗敏,曹红平,钟彦,刘军,王一慧,刘昕,张年辉, and刘科*. (2009)出芽酵母Saccharomyces cerevisiae转录抑制因子Rdr1负调控细胞胁迫应答.生物化学与生物物理进展v.36, 1544-1552
11.曹红平,王一慧,钟彦,刘昕,苗敏,刘科*. (2009)过量表达蛋白激酶YPK1使酵母细胞对高盐胁迫的高度敏感依赖于雷帕霉素靶蛋白.微生物学报v.49;No.v.49, 1069-1074
12. Zhang, W., Smith, A., Liu, J. P., Cheung, N. S., Zhou, S.,Liu, K., Li, Q. T., and Duan, W. (2009) GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner.Cellular signalling21, 237-245
13.袁瀚,韩璐,杜立波,田秋,刘科,杜林方,刘扬. (2008)单细胞光合生物莱茵衣藻光系统Ⅱ产生超氧阴离子自由基的ESR研究.生物化学与生物物理进展, 1065-1069
14. Lim, W. G., Chen, X., Liu, J. P., Tan, B. J., Zhou, S., Smith, A., Lees, N., Hou, L., Gu, F., Yu, X. Y., Du, Y., Smith, D., Verma, C.,Liu, K.*, and Duan, W.* (2008) The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.Archives of biochemistry and biophysics479, 170-178
15.Liu, K., Zhang, X., Sumanasekera, C., Lester, R. L., and Dickson, R. C. (2005) Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae.Biochemical Society transactions33, 1170-1173
16.Liu, K., Zhang, X., Lester, R. L., and Dickson, R. C. (2005) The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.The Journal of biological chemistry280, 22679-22687
17.Liu, K., Sun, J., Song, Y. G., Liu, B., Xu, Y. K., Zhang, S. X., Tian, Q., and Liu, Y. (2004) Superoxide, Hydrogen Peroxide and Hydroxyl Radical in D1/D2/cytochrome b-559 Photosystem II Reaction Center Complex.Photosynthesis research81, 41-47
18. Xu, Y. K., Chen, Z. W., Sun, J.,Liu, K., Chen, W., Shi, W., Wang, H. M., and Liu, Y. (2002) Synthesis, crystal structure, and ESR study of a novel phosphorylated lipophilic spin trap.The Journal of organic chemistry67, 7624-7630
19.刘科,孙健,徐英凯,陈中伟,张启元,张兴康,匡廷云,刘扬. (2001)光系统Ⅱ颗粒内单线态氧诱导产生超氧阴离子自由基.植物学报, 988-990
20.刘科,孙健,刘扬,张启元,匡廷云. (2001)高等植物光系统Ⅱ中强光照射产生超氧阴离子自由基的ESR探索.生物化学与生物物理进展, 372-376
