邹方东 教授 博导
兼职:
教育部高等学校大学生物学教学指导委员会委员
四川大学生命科学学院院长助理、生物系系主任、
中国细胞生物学学会常务理事兼教学与普及工作委员会秘书长
四川省细胞生物学会副理事长
电话:
028-85412805
Email:
fundzou@163.com
fundzou@scu.edu.cn
简历:
1994年西南大学本科毕业，获学士学位
1997年四川大学细胞遗传硕士毕业，同年留校任教
2002年香港中文大学做访问学者，同年破格晋升为副教授
2005年获得四川大学理学博士学位
2007.1-2008.1在University of Pittsburgh国家公派访问学者
2013.11-2014.1在University of Pittsburgh国家公派高级访问学者
2007年起任四川大学教授和博士生导师
研究方向:
主要研究细胞增殖、分化以及细胞凋亡、自噬过程中，细胞命运转变的分子调控机制，并关注药物对细胞命运调控的作用机制及细胞耐药产生机制。
主要论文(*通讯作者):
1. Dong Yang, Bin Sun, Xiaohong Zhang, Daomei Cheng, Xiaoping Yu, Lanzhen Yan, Lei Li, Sanqi An, Hua Jiang, Anna Lasorella, Antonio Iavarone, Shu Zhang,Fangdong Zou*, Xudong Zhao*, Huwe1 sustains normal ovarian epithelial cell transformation and tumor growth through the histone H1.3-H19 cascade,Cancer Research, 2017, Sept 15, 77(18):4773-4784
2. Shu Gong, Dongsheng Xu,Fangdong Zou*,Rui Peng, (−)-Curine induces cell cycle arrest and cell death in hepatocellular carcinoma cells in a p53-independent way,Biomedicine & Pharmacotherapy, 2017, 89: 894–901
3. Jingshan Tong#, Shuai Tan#, Zaneta Nikolovska-Coleska, Jian Yu,Fangdong Zou*, Lin Zhang*,FBW7-dependent Mcl-1 degradation mediates the anticancer effect of Hsp90 inhibitors,Molecular Cancer Therapeutics, 2017. Sep, 16(9):1979-1988
4. Jingshan Tong, Peng Wang, Shuai Tan, Dongshi Chen, Zaneta Nikolovska-Coleska,Fangdong Zou, Jian Yu, and Lin Zhang*, Mcl-1 degradation is required for colon cancer cell killing by targeted therapy,Cancer Research, 2017 May 1, 77(9): 2512-2521
5. Shengwei Li, Xiaoping Gao, Rui Peng, Sheng Zhang, Wei Fu, Fangdong Zou*, FISH-based analysis of clonally derived CHO cell populations reveals high probability for transgene integration in a terminal region of chromosome 1 (1q13),Plos One, 2016 DOI:10.1371/ journal.pone.0163893
6. JingShan Tong, Shuai Tan,Fangdong Zou, Jian Yu and Lin Zhang, FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation,Oncogene, 2017 February 09; 36(6): 787–796
7. Brown M, Leibowitz B, Chen D, He K,Fangdong Zou, Sobol R, Stolz D, Zhang L, Yu J*, Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.Cell Death & Disease,2015 Apr 23;6:e1729. doi: 10.1038/cddis.2015.104
8. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang,Fangdong Zou*, Qing Jiang, Chuanmao Zhang*, Spatial compartmentalization specializes function of Aurora-A and Aurora-B,Journal of Biological Chemistry, 2015. 290: 17546-17558
9. Brian Leibowitz, Wei Qiu, Monica E. Buchanan,Fangdong Zou, Philip Vernon, Mary Pat Moyer, Xiao-Ming Yin, Robert E. Schoen, Jian Yu*, and Lin Zhang*, BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs,Proc Natl Acad Sci USA,2014 Nov 18;111(46):16520-16525
10. Dongshi Chen, Lihua Ming, Fangdong Zou,Ye Peng, Bennett Van Houten, Jian Yu, Lin Zhang, TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity,Oncotarget, 2014, 5(18): 8107-8122.
11. Rui Peng, Jingshan Tong, Hua Li, Bisong Yue,Fangdong Zou*,Jian Yu, Lin Zhang*，Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation,Cell Death and Differentiation, 2013, 20: 744-754（IF8.339，获Faculty 1000推荐）
12. Si Li, Zhu Liang, Liu Xu,Fangdong Zou*, microRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases,Molecular and Cellular Biochemistry, 2012, 360: 147-158
13. Li Ou, Xiaochen Wang andFangdong Zou*, Is iPS cell the panacea?IUBMB Life, 2010, 62(3): 170-175
14. Peng Wang#,Fangdong Zou#（Co-first author）, Xiaodong Zhang, Hua Li, Austin Dulak, Robert J. Tomko, Jr., John S. Lazo, Zhenghe Wang, Lin Zhang, and Jian Yu*,microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells,Cancer Research, 2009, 69 (20): 8157-8165 (IF 9.122)被引用300次，据Web of Science，学术领域中最优秀的Top 1%论文
15. Yan Fan, Zan Tong, Jiefang You,Fangdong Zou*, Mingxiao Ding, Hongkui Deng, Nanog reporter system in mouse embryonic stem cells based on high efficient BAC homologous recombination,Chinese Science Bulletin, 2007, 52 (2): 2782-2788.
