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黄 震
作者: user -- 发布时间:2015/3/18

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黄震 教授 博导

 

黄震教授实验室网址:http://lithium.gsu.edu/faculty/Huang/

简介:

黄震教授是中国国家千人计划专家。他是中美化学及化学生物学教授协会(CAPA) 第一任主席,以及三位创始人之一。他为学术界做了很多工作,为中美学术和科技交流做出了积极贡献。他被选为中国和美国联邦政府研究基金的评审员以及国际多种高端学术刊物的评审员。他曾担任多本书藉刊物的编辑或客座编辑。黄震教授曾就读于四川大学北京大学瑞士苏黎世联邦理工大学,以及哈佛大学医学院师从2009年诺贝尔医学奖得主杰克·邵斯达克(Jack Szostak)教授。

他是硒核酸、RNA核酸基因芯片、硒核酸生物平台技术及其硒核酸晶体结构研究的独创发明人。他在《美国化学会杂志》,《德国应用化学》,《核酸研究》及其他专业杂志和刊物上发表文章100多篇。他的研究项目多次获奖。他曾独立获得21项研究基金,其中包括美国联邦政府研究基金、美国佐治亚州政府研究基金、癌症研究杰出专家基金和企业界研究基金的支持。其研究项目已经获得或正在申请中国、美国、欧洲及国专利及发明(30多项)。他也使用自己发明的创新技术来积极推动大核酸产业的发展以及生物医药技术的进步。

联系方式:

邮箱:zhen_huang@scu.edu.cn         电话:028-85502629

简历:

1980-1984年,获得四川大学学士学位,分析化学专业

1984-1987年,获得北京大学硕士学位,生物有机化学专业

1988-1994年,获得瑞士苏黎世联邦理工大学ETH, Zurich)博士学位,化学生物学专业

1994-1998年,哈佛大学医学院遗传系博士后, 从师于 2009年诺贝尔医学奖得主邵斯达克教授 (Professor Jack Szostak)

1998年,  被聘入纽约城市大学布鲁克伦学院为助理教授

2004年,  升为副教授,并被聘入乔治亚州立大学化学系

2009年,  升为乔治亚州立大学终身正教授,获大学杰出教授奖,并为美国佐治亚州癌症研究杰出研究员

2014今,四川大学生命科学学院正教授

其他经验和专业成员:

2007 – 2010  第一任主席,中美化学及化学生物学教授协会(CAPA)

2007 – 今    成员,美国癌症研究协会

2006 – 今    成员,美国晶体学协会

2002-2004   主席,美国青年化学家协会(YACS)

1997-1998   主席,美国华人生物化学家协会(ABC),波士顿

1994- 今     成员,美国化学学会       

研究方向:

目前他的主要研究兴趣包括: 硒核酸以及碲核酸创新性研究,包括生物化学合成,核糖核酸衍生化核酸及核酸-蛋白复合物晶体结构及功能研究,以核酸和核酸-蛋白复合物结构测定为基础的新药研发核酸适配体和核酶的筛选及功能研究,疾病的核酸检测诊断,核酸基因测序,高保真碱基识别与RNA芯片,核酸抗肿瘤药物研究

奖项和专业活动:

2010 – 今    中国科学化学编委会成员

2008-2013   乔治亚州癌症研究杰出科学家奖(GCC)

2008   乔治亚州立大学杰出教授奖

2008   乔治亚州立大学教授成就奖

2008   CAPA杰出教授奖

教学经验:

1.核酸的化学和生物合成,抗癌药物的发现,核酸-蛋白大分子结构,机理研究和核酸检测

2. 化学和药物治疗

3. 高级化学生物学和生物有机化学

4. 高级有机合成和机理

部分申请和已获得的专利:

1.        Zhen Huang, Title: “RNA MICROCHIP DETECTION USING NANOPARTICLE-ASSISTED SIGNAL AMPLIFICATION”, 2014, PCT, filed.

2.        Zhen Huang, Title: “METHODS AND COMPOSITIONS FOR INTERFERENCE WITH DNA POLYMERASE AND DNA SYNTHESIS”, 2013, US provisional application, filed.

3.        Zhen Huang, Title: “NANOPARTICLE-ASSISTED RAPID RNA DETECTION ON RNA MICROARRAY”, 2013, US provisional application, filed.

4.        Zhen Huang, Title: “Facile SELENIUM CONTAINING NUCLEOSIDES AS NUTRITIONAL SUPPLEMENTS”, 2013, PCT, filed.

5.        Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2013, Chinese Patent pending. 

6.        Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2013, US Patent, 8,354,524.

7.        Zhen Huang, Title: “RNA Selective Detection and Quantitation Using Chip and Plate”, 2012, European Patent 1668158.

8.        Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent 12/562,960. 

9.        Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent Application (divisional), 13/172,559. 

10.     Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, U.S. Provisional Application No.: 61/375,992.

11.     Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2010, U.S. Patent Application No. 12/933,619 (National Phase Filing of PCT/US09/37823).

12.     Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, US provisional patent, 61/375,560.

13.     Zhen Huang, Title: “RNA Detection and Quantitation”, 2010, Oct. 20, European Patent, WO 2005/019469. 

14.     Zhen Huang, Title: “Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy”, 2010, US provisional patent, 61/382,154.

15.     Zhen Huang, Jia Sheng, Title: “Novel Compounds and Synthesis of Tellurium-derivatized Oligonucleotides for Structural and Functional Studies”, 2010, PCT/US10/36639.

16.     Zhen Huang, Abdalla Hassan, Jia Sheng and Wen Zhang, Title: “Novel Compound and Derivatizaton of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics”, 2010, PCT/US10/35631.

17.     Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2010, US Patent, US7,982,030.

18.     Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2009, US Patent, US 7,592,446.

19.     . Zhen Huang, Abdalla Hassan and Wen Zhang, Title: “Derivatization of DNAs and RNAs at 5-positions of pyrimidines for function, structure, and therapeutics”, 2009, US Provisional Patent Application, 60/180,028.

20.     Zhen Huang, Jia Sheng and Abdalla Hassan, Title: “Novel Compounds and Derivatization of DNAs and RNAs at the 2' and 5-positions of pyrimidines with tellurium functionalities for function, structure, imaging, diagnosis, and therapeutics”, 2009, US Provisional Patent Application, 61/182,580.

21.     Zhen Huang and Sarah Spencer, Title: “RNA Microchip for Rapid, Direct and Specific Detection of RNAs”, 2009, US Provisional Patent Application, 61/252,940

22.     Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2009, PCT Patent Application, International application No. PCT/US2009/037823.

23.     Zhen Huang, Title: “Se-containing nucleosides, synthesis methods, and anti-cancer activity”, 2008, US Provisional Patent Application, 61/083,815.

代表性论文:

24.     Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff3, Zhen Huang*, Weihong Tan* and Steven A. Benner*, “Crystal Structure, Evolution, and Function of Six-Nucleotide DNA. Exploring its Large Sequence Space”Journal of American Chemical Society, 2015, 137, 67346737.

25.     Rob Abdur, Oksana O. Gerlits, Jianhua Gan, Jiansheng Jiang, Jozef Salon, Andrey Y. Kovalevsky, Alexander Chumanevich, Irene T. Weber, Zhen Huang*, “Novel Complex MAD Phasing and RNase H Structural Insights by Selenium Oligonucleotides”, Acta Crystallographica Section D, 2014, D70, 354-361.

26.     Jia Sheng, Jianhua Gan, Alexie Soars, Jozef Salon and Zhen Huang*, “Structural Insights of Non-canonical U•U Pair and Hoogsteen Interaction Probed with Se Atom”, 2013, Nucleic Acids Research, 41, 10476-10487.

27.     Jia Sheng, Jianhua Gan and Zhen Huang*, “Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery”, Medicinal Research Reviews, 2013, 33, 1119-1173.

28.     Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, and Zhen Huang*, “2-Selenouridine Triphosphate Synthesis and Se-RNA Transcription”, RNA, 2013, 19, 1309-1314.

29.     Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone", Nucleic Acids Research, 2012, 40, 8111-8118.

30.     Huiyan Sun, Jia Sheng, Abdalla E. A. Hassan, Sibo Jiang, Jianhua Gan and Zhen Huang*,Novel RNA Base Pair with Higher Specificity using Single Selenium Atom”, Nucleic Acids Res., 2012, 40, 5171-5179.

31.     Wen Zhang, Jia Sheng, Abdalla E. Hassan, and Zhen Huang*, "Synthesis of Novel 2’-Deoxy-5-(Methylselenyl)Cytidine and Se-DNAs for Structure and Function Studies", Chemistry-An Asian Journal, 2012, 7, 476-479.

32.     Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, "Synthesis, Structure and Imaging of Oligodeoxyribonucleotides with Tellurium-nucleobase Derivatization", Nucleic Acids Research, 2011, 39, 3962-3971.

33.     Wen Zhang and Zhen Huang*, "Synthesis of the 5’-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide", Organic Letter, 2011, 13, 2000-2003.

34.     Julianne Caton-Williams, Lina Lin, Mathew Smith, and Zhen Huang*, "Convenient Synthesis of Nucleoside 5’-Triphosphates for RNA Transcription", Chemical Communications, 2011, 47, 8142-8144.

35.     Lina Lin, Julianne Caton-Williams, Manindar Kaur, Andres M. Patino, Jia Sheng, Jaya Punetha, and Zhen Huang*, "Facile Synthesis of Nucleoside 5’-(alpha-P-seleno)-triphosphates and Phosphoroselenoate RNA Transcription", RNA, 2011, 1932-1938.

36.     Lina Lin, Jia Sheng, and Zhen Huang*, "Nucleic Acid X-ray Crystallography via Direct Selenium Derivatization", Chemical Society Reviews (invited and peer reviewed), 2011, 40, 4591-4602.

37.     Khin Lay Maw, Julianne Caton-Williams, Jozef Salon, Zhen Huang*, "Simple UV and HPLC Methods for the Evaluation of Sunscreen Efficacy", Journal of the American Academy of Dermatology, 2011, 65, 328-335. ##

38.     Abdalla E. A. Hassan, Jia Sheng, Wen Zhang, and Zhen Huang*, "High Fidelity of Base Paring by 2-Selenothymidine in DNA", Journal of American Chemical Society, 2010, 132, 2120-2121. ##

39.     Jia Sheng, Abdalla Hassan, Zhen Huang*, "Synthesis of the First Tellurium-Derivatized Oligonucleotides for Structural and Functional Studies", Chemistry - A European Journal, 2009, 15, 10210-10216. ##

40.     Julianne Caton-Williams and Zhen Huang*, "Synthesis of Colored 4-Selenothymidine Triphosphate and its DNA Polymerase Incorporation into DNAs for Visualization, Structure and Function Studies", Angew. Chem. Int. Ed., 2008, 47, 1723-1725. ##  

41.     Jozef Salon, Jiansheng Jiang, Jia Sheng, Oksana O. Gerlits, Zhen Huang*, "Derivatization of DNAs with Selenium at 6-Position of Guanine for Function and Crystal Structure Studies", Nucleic Acids Research, 2008, 36, 7009-7018. ##

42.     Jozef Salon, Jia Sheng, Jiansheng Jiang, Guexiong Chen, Julianne Caton-Williams, Zhen Huang*, “Oxygen Replacement with Selenium at the Thymidine 4-position for the Se-Base-Paring and Crystal Structure Studies”, Journal of American Chemical Society, 2007, 129, 4862-4863. ##

43.     Jiansheng Jiang, Jia Sheng, Nicolas Carrasco, and Zhen Huang*, “Selenium Derivatization of Nucleic Acids for Crystallography”, Nucleic Acids Research, 2007, 35, 477-485. ##

44.     Jozef Salon, Guexiong Chen, Yoani Portilla, Markus W. Germann, and Zhen Huang*, “Synthesis of a Novel 2’-Se-uridine Phosphoramidite and Its Incorporation into Oligonucleotides for Structure Study”, Organic Letters, 2005, 7, 5645-5648. ##

45.     Nicolas Carrasco and Zhen Huang*, “Enzymatic Synthesis of Phosphoroselenoate DNA using Thymidine  5’-(a-P-Seleno)-triphosphate and DNA Polymerase for X-ray Crystallography using MAD”, Journal of American Chemical Society, 2004, 126, 448-449. #

46.     Nicolas Carrasco, Yuri Buzin, Elizabeth Tyson, Elizer Halpert, and Zhen Huang*, Selenium Derivatization and Crystallization of DNA and RNA Oligonucleotides for X-ray Crystallography Using Multiple Anomalous Dispersion”, Nucleic Acids Research, 2004, 32, 1638-1646. #

47.     Zhen Huang* and Jack W. Szostak, “Evolution of Aptamers with a New Specificity and New Secondary Structures from an ATP Aptamer”, RNA, 2003, 9, 1456-1463. #

48.     Quan Du, Nicolas Carrasco, Marianna Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang*, “Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD”, Journal of American Chemical Society, 2002, 124, 24-25. #

49.     Nicolas Carrasco, Dov Ginsburg, Quan Du, and Zhen Huang*, “Synthesis of Selenium-Derivatized Nucleosides and Oligonucleotides for X-ray Crystallography”, Nucleosides, Nucleotides, & Nucleic Acids, 2001, 20, 1723-1734.



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