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王亚军
作者: user -- 发布时间:2017/9/25 20:28:37

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博士、教授、博士生导师

联系方式:办公室电话:028-85415025
电子邮件:cdwyjhk@gmail.comcdwyjhk@163.com


一、学习与工作简历

1987-1991:  西南大学 生命科学学院 理学学士

1991-1994:  四川大学 生物系 硕士

1994-1999:  四川大学 生物系 助教、讲师

1999-2003:  香港中文大学(The Chinese University of Hong Kong) 博士

2003-2004:  香港中文大学 博士后

2004-2007:  香港大学 (The University of Hong Kong) 博士后

2007-2009:  香港大学 研究助理教授

2009-现在: 四川大学 生命科学学院 教授

 

二、研究简介

  王亚军教授任职于四川大学生命科学学院,细胞生物学方向博士生导师。王亚军教授博士期间(1999-2003)致力于动物卵泡发育机制解析,以斑马鱼为模型,探究EGF、Activin等对卵泡发育的调节。完成博士学位攻读后,王亚军教授入职香港大学生物科学院,以家鸡为模型,致力于基因功能鉴定,探究动物生长、繁殖与代谢调控机理。

  2009年,王亚军教授全职回到四川大学,在“四川大学引进人才基金”支持下,组建动物功能基因组学研究平台,主以家鸡(或斑马鱼)等为模型,探究:1) 受体功能与信号传导;2) 下丘脑神经元对垂体功能的调节;3) 垂体激素对动物生长,繁殖与代谢的影响;4) 肠道微生物对动物免疫与代谢等过程的调节;5) 动物基因编辑与转基因技术。

 

三、研究方向

动物细胞生物学、 信号传导、 内分泌与代谢、分子遗传学

 

四、学术兼职:

担任SCI杂志《Frontiers in Physiology》(IF=4.134)-Avian Physiology方向副主编(Associate Editor)

 

代表性论文:

 

1.  Zhang J, Li X, Zhou Y, Cui L, Li J, Wu C, Wan Y, Li J, Wang Y (2017). The interaction of MC3R and MC4R with MRAP2, ACTH, α-MSH and AgRP in chickens. Journal of Endocrinology 234: 234: 155-174 (通讯) (IF = 4.706)

 

2.  Mo C, Huang L, Cui L, Lv C, Lin D, Song L, Zhu G, Li J, Wang Y (2017) Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. Journal of Molecular Endocrinology, 59: 61-79. (通讯) (IF = 3.577) (杂志封面图片)

 

3.  Cui L, Lv C, Zhang J, Mo C, Lin D, Li J, Wang Y (2107). Characterization of melanin-concentrating hormone (MCH) and its receptor in chickens: Tissue expression, functional analysis, and fasting-induced up-regulation of hypothalamic MCH expression. Gene 615:57-67. (通讯) (IF = 2.42)

 

4.  Gao S, Zhang J, He C, Meng F, Bu G, Zhu G, Li J, Wang Y (2017). Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens. General and Comparative Endocrinology 240, 46–60 (通讯) (IF = 2.585)

 

5.  Bu G, Lin D, Cui L, Huang L, Lv C, Huang S, Wan Y, Fang C, Li J, Wang Y. (2016) Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion. Endocrinology 157:3562-76. (通讯) (Endocrinology 杂志撰文评论) (IF = 4.286).

 

6.  He C, Zhang J, Gao S, Meng F, Bu G, Li J, Wang Y (2016) Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis. General and Comparative Endocrinology, 236: 24–34 (通讯) (IF = 2.585).

 

7.  Tachibana T., Kubo S., Khan M.S.I., Masuda K., Ukena K., Wang Y (2016). Peripheral injection of chicken growth hormone-releasing hormone inhibits feeding behavior in chicks. Journal of Poultry Science, 53, 29-33 (IF=0.771).

 

8.  Mo C, Cai G, Huang L, Deng Q, Lin D, Cui L, Wang Y, Li J (2015). Corticotropin-releasing Hormone (CRH) Stimulates Cocaine- and amphetamine-regulated Transcript Gene (CART1) Expression through CRH Type 1 Receptor (CRHR1) in Chicken Anterior Pituitary. Molecular and Cellular Endocrinology 417: 166-177 (IF= 3.859)

 

9.  Cai G, Mo C, Huang L, Li J, Wang Y (2015). Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus). PLoS One 10(5):e0127107. doi: 10.1371 (通讯) (IF = 3.057).

 

10. Bu G, Liang X, Li J, Wang Y (2015). Extra-pituitary Prolactin (PRL) and Prolactin-like Protein (PRL-L) in Chickens and Zebrafish. General and Comparative Endocrinology 220:143-153 (通讯) (IF = 2.667).

 

11. Tachibana T, Sugimoto I, Ogino M, Khan MS, Masuda K, Ukena K, Wang Y (2015). Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks. Physiology & Behavior. 139:195-201 (IF=2.461).

 

12. Li X, Fang W, Hu Y, Wang Y, Li J (2015). Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Gene, 570: 221-229. (IF = 2.319).

 

13. Huang G, He C, Meng F, Li J, Zhang J, Wang Y (2014). Glucagon-Like Peptide (GCGL) Is a Novel Potential TSH-Releasing Factor (TRF) in Chickens: I) Evidence for Its Potent and Specific Action on Stimulating TSH mRNA Expression and Secretion. Endocrinology, 155: 4568-4580 (通讯) (IF = 4.503)

 

14. Huang G, Li J, Wang H, Lan X, and Wang Y (2014). Discovery of a Novel Functional Leptin Protein (LEP) in Zebra Finches: Evidence for the Existence of an Authentic Avian Leptin Gene Predominantly Expressed in the Brain and Pituitary. Endocrinology155: 3385-96 (通讯) (Endocrinology 20149月封面论文,并获杂志撰文评述) (IF = 4.503)

 

15. Meng F, Huang G, Gao S, Li J, Yan Z, Wang Y (2014). Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1–27NH2-induced growth hormone secretion in cultured chicken pituitary cells. Molecular and Cellular Endocrinology 384: 83-95 (通讯) (IF= 4.405)

 

16. Mo C, Zhong Y, Wang Y, Yan Z, Li J (2014). Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine. Domestic Animal Endocrinology 481-6 (通讯) (IF = 2.171).

 

17. Zhang J, Cheng S, Wang Y, Yu X, Li J. (2014). Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species. Domestic Animal Endocrinology 47:108-118 (通讯) (IF =2.171).

 

18. He X, Meng F, Wang Y, Li J (2014). Molecular Cloning and Characterization of Two Pig Vasoactive Intestinal Polypeptide Receptors (VPAC1-R and VPAC2-R). DNA Cell Biol. 33259-270 (IF=2.055).

 

19. Bu G, Wang CY, Cai G, Leung FC, Xu M, Wang H, Huang G, Li J, Wang Y (2013) Molecular Characterization of Prolactin Receptor (cPRLR) Gene in Chickens: Gene Structure, Tissue Expression, Promoter Analysis, and Its Interaction with Chicken Prolactin (cPRL) and Prolactin-like Protein (cPRL-L). Molecular and Cellular Endocrinology 370: 149-62.通讯(IF = 4.241).

 

20. Bu G, Huang G, Fu H, Li J, Huang S. Wang Y2013Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens. Journal of Molecular Endocrinology 51, 261–276通讯(IF = 3.621).

 

21. Song X, Wang Y, Tang Y (2013) Rapid Diversification of FoxP2 in Teleosts through Gene Duplication in the Teleost-Specific Whole Genome Duplication Event. PLoS One 8 (12):e83858.通讯(IF = 3.534).

 

22. Wang Y, Meng F, Zhong Y, Huang G, Li J (2012) Discovery of a Novel Glucagon-like Peptide (GCGL) and its Receptor (GCGLR) in Chickens: Evidence for the Existence of GCGL and GCGLR Genes in Non-mammalian Vertebrates. Endocrinology 153, 5247-5260 (通讯) (IF = 4.717).

 

23. Wang Y, Wang CY, Wu Y, Huang G, Li J, Leung FC (2012). Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology 153: 1861-1874 (通讯) (IF = 4.717).

 

24. Wang Y, Huang G, Li J., Meng F, He X. Leung F.C (2012) Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology 348: 270-280 (通讯) (IF=4.192)

 

25. Ho JCW, Jacobs T, Wang Y, Leung FC (2012) Identification and characterization of the chicken galanin receptor GalR2 and a novel GalR2-like receptor (GalR2-L). General and comparative endocrinology 179: 305-312 (通讯) (IF=2.823)

 

26. Kwok AHY, Wang Y, Leung FC (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 3 (EP3) in chickens. General and comparative Endocrinology 179: 88-98 (通讯) (IF=2.823)

 

27. Kwok AHY, Wang Y, Leung FC (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish. General and comparative Endocrinology 178: 216-226 (通讯) (IF=2.823)

 

28. Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y (2012) Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology 43: 1-15 (通讯) (IF=2.377).

 

29. Li J, Meng F, Song C, Wang Y, Leung FC (2012) Characterization of chicken visfatin gene: cDNA cloning, Tissue expression, and promoter analysis. Poultry Science 91: 2885-94 (IF=1.728).

 

30. Ho JC, Kwok AH, Zhao D, Wang Y, Leung FC. (2011) Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, (通讯) (IF=3.267).

 

31. Ruiqiang Li#, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang (2010). The sequence and de novo assembly of the giant panda genome. Nature 463: 311-317 (IF=36.101).

 

32. Wang Y, Li J, Kwok AHY, Ge W, Leung FC (2010) A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative Endocrinology 166: 200-210 (IF=3.108).

 

33. Wang Y, Li J, Wang CY, Kwok AHY, Leung FC (2010) Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38:13-31. (IF=2.056).

 

34. Lynch VJTanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP (2008), Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105:14925-14933 (IF=9.598).

 

35. Wang J, Wang Y, Li X, Li Juan, Leung FC (2008) Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688 (IF=1.603).

 

36. Kwok AHY, Wang Y, Wang CY, Leung FC. (2008), Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4). General and Comparative Endocrinology, 157: 99-106 (IF=2.823)

 

37. Wang Y, Li J, Wang CY, Kwok AHY, Leung FC (2007) Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology148: 2405-2416 (IF=5.045)

 

38. Wang Y, Li JWang CY, Kwok AHY, Leung FC (2007) Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440. (IF=5.045)

 

39. Wang Y, Wang Z, Li J, Wang Y, Leung FC (2007) A database for chicken full-length cDNAs. Physiological Genomics 28:141-5 (IF=3.498)

 

40. Kwok AHY, Wang Y, Wang CY, Leung FC. (2007), Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430 (IF=1.603)

 

41. Wang CY#, Wang Y#, Kwok AHY, Leung FC (2007). Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536 (IF=2.636)( #同等贡献).

 

42. Wang CY, Wang Y, Li J, Leung FC (2006) Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science 85: 569-576 (IF=1.603)

 

43. Kwok HF, So WK, Wang Y, Ge W (2005) Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction 72: 1370-1381 (IF=3.670)

 

44. Wang Y & Ge W (2004) Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction 71: 749-760 (IF=3.670)

 

45. Wang Y & Ge W (2004). Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction 71: 2056-2064 (IF=3.670)

 

46. Wang Y & Ge W (2004). Cloning of zebrafish ovarian P450c17 (CYP17, 17α-hydroxylase/ 17,20- lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology 135: 241-249 (IF=3.108).

 

47. Wang Y & Ge W (2003) Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144: 491-499 (IF=5.045).

 

48. Wang Y, Wong AOL & Ge W (2003) Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology 144: 4799-4810 (IF=5.045).

 

49. Wang Y & Ge W (2003) Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction 69: 1998-2006 (IF=3.670).

 

50. Wang Y & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology 134: 308-315 (IF=3.108).

 

51. Wang Y & Ge W (2002) Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology 127: 209-216 (IF=3.108).

 

科研用书章节撰写(Book Chapter)

 

1.   Wang Yajun (2017): Chapter 12: Novel Peptides in PoultryA case study of the expanding glucagon peptide superfamily in chickens (Gallus gallus). Book Title: <Biology of Domestic Animals>, Edited by Scanes CG & Hill Rp343-352 (CRC Press, 1st Edition).

 

国际会议报告

 

1.    王亚军 The 11th International Symposium on Avian Endocrinology 2016 (ISAE2016) (Canada, 2016) (大会报告, 25 min. Invited Speaker).

Title: Molecular Characterization of the Key Regulators in Avian Energy Balance: A Tale in Birds.

 

2.   王亚军  Physiology2014 (London UK, The Physiological Society, 2014) (Invited Speaker) Title: Extra-pituitary Prolactin and Prolactin-like Hormone in Zebrafish and Chickens.

 

3.   王亚军  The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (Japan, 2012). (大会报告, 25min. Invited Speaker).

Title: Molecular Characterization of the Receptors for Chicken GHRH, PrRP, and Their Related Peptides: An Emerging Evolutionary Story.

 

获奖:

 

2003年度香港中文大学研究生最佳研究成绩奖


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