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高 荣
作者: user -- 发布时间:2012/2/10 20:20:54

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高荣,男;汉族,博士,教授,博士生导师,四川省学术和技术带头人。

电话:028-85411033(lab),028-85471599(office);

emailgaorong@scu.edu.cn;gaorong96@163.com

 

四川大学生物资源与生态环境教育部重点实验室副主任;

《Biomaterial》、《Vaccine》、《Immunology》、《Nanomedicine》和《Research in Veterinary Science》等国际SCI学术期特邀刊审稿专家;

 

学习和工作简历:

1981.09-1985.07:动物医学本科毕业,学士;

1985.9-1988.6:免疫病理硕士研究生, 硕士;

1988.07-1991.07: 硕士,参加工作;助教、讲师;

1991.09-1994.12: 讲师;在职博士研究生,博士;

1995.01-1996.02:东北农业大学,副教授;

1996.03-至今:四川大学生命科学学院,副教授,教授;

2004.11:访问美国Missouri University、Stanford University、Kansas University,California University in Los Angeles and San Francisco,California Institute of Technology

2005-2006年:到澳大利亚Melbourne University、Victoria University、Monash University、美国Harvard University、Massachusetts Institute of TechnologyBoston University、Washington University 、Maryland University访问与学术交流;;

2007-2008年:丹麦Denmark Technical University访问学者、到Copenhagen University、英国Cambridge University、Oxford University学术交流与合作研究;

2009.06-09:到比利时Veterinary and Agrochemical research Centre、德国Hannover University和新加坡国立大学访问和学术交流;

2010年:德国Leipzig University、法国的ONCFS研究所、美国 California University of Berkley、California University of San Diego、Chicago University、Massachusetts Institute of Technology访问与学术交流;

2011.11:访问西班牙Barcelona University 、Olot Pfizer company和瑞士IVI(Institute of Virology and Immunoprophylaxis)和学术交流;

2012.11-12到匈牙利布达佩斯、葡萄牙和荷兰中央兽医研究所参加国际学术会议和欧盟国际合作项目会议交流。

 

主要研究方向及内容、主要成绩:

研究方向包括:分子遗传和基因工程、分子免疫学、生物技术、微生物学和动物传染病;主要开展动物表观遗传学、动物分子免疫、动物生长发育和代谢调节、新疫苗研制、免疫应答调节和新型抗感染免疫分子制剂的研究探索;

着重利用我国丰富的生物基因资源,克隆分离免疫抗感染、生长发育和代谢调控相关功能基因和分子,鉴定其功能活性;以现代分子生物学、遗传学、分子免疫学、生物信息学和结构生物学等理论为指导,用生物工程技术修饰和改造生物分子结构,提高其生物调节活性;结合纳米生物材料技术,研制协调增强动物免疫防御、抗应激和促进动物生长发育和代谢调节的系列新型分子制剂;防治传染性疾病,控制微生物感染,调节动物生长发育、保障和促进动物健康生长,并改善动物营养成分,提高其营养价值。

已承担主持欧盟国际合作项目、科技部国际合作专项、国家自然科学基金、国家863计划、国家支撑计划、重大基础研究项目、教育部、四川省等20多项重点科研课题研究;已在国内外核心学术刊物发表科研论文90多篇,其中SCI、EI论文40多篇,部分成果已获国家科技进步二等奖1项,省级科技进步二等奖4项,省教委科技进步一等奖1项、二等奖1项;已获得或申请技术发明专利共计19项;培养、指导硕士生、博士生和博士后50余人。

近期主要论文

1.        Yanyue Li, Xiaocheng Li,Wen-kui Sun, Chi Cheng, Rong Gao, Rui Liu, Xuebin Lv,  Comparison of liver microRNA transcriptomes of Tibetan and Yorkshire pigs by deep sequencingGene2016, 577(2): 244–250

2.        Jianlin Chen, Gang Wang, Zhongwei Gu, Rong Gao, et al. Increase in Transgene Expression by Pluronic L64-Mediated Endosomal/Lysosomal Escape through Its Membrane-Disturbing Action ACS Applied Materials & Interfaces2015, 7, 72827293

3.        Jing Luo, Jianlin ChenGang WangRong Gao et al. An efficient method for in vitro gene delivery via regulation of cellular endocytosis pathway International Journal of Nanomedicine 201510 112

4.        Chi Cheng, Wenkui Sun, R. Liu, R. M. Wang, XB. Lu and R. Gao, Comparison of gene expression of Toll-like receptors and antimicrobial peptides in immune organs and tissues between Yorkshire and Tibetan pigsAnimal Genetics 2015,46, 272279

5.        Xiaoping Wan, Xiao Yang, Suqiong Zhan, Jianlin Chen, Rong Gao, Cloning of interleukin-15 gene of Tibetan pig and adjuvant effect of its recombinant plasmids packed with PEG and PEI modified chitosan nanoparticles on immunity of mice to FMD vaccination, Procedia in Vaccinology 9 ( 2015 ) 80 – 90

6.        Dong Li, Jian-Lin Chen, Huan ZhangXiao Yang, Xiao-Ping Wan, Chi Cheng, Yue Li, Ze-Zhou Wang, Xue-Bin Lv, Hong-Ning Wang, Jiang-Ling Li, Rong GaoImprovement of the immunity of pig to Hog cholera vaccine by recombinant plasmid with porcine interleukin-6 gene and CpG motifsVaccine2011293888–3894

7.        Yuanyuan Yu, Zheng Wang, Lin Cai, Gang Wang, Xiao Yang, Xiao Pin Wan, Xin Hua Xu,Ying Li, Rong Gao. Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine for gene deliveryCarbohydrate Polymers 201081 (2): 269-274corresponding author)

8.        Yang, X; Sun, WK; Chen, WL; Chen, JL; Wan, XP; Zhang, H;  Cai, L; Wang, ZZ; Lv, XB; Wang, HN; Li, JL; Gao, R. Promotion of the immunity of piglets to Hog cholera vaccine induced by shuffled pig interleukin-2 gene and CpG immunostimulatory sequences encapsulated in chitosan nanoparticlesProcedia in Vaccinology2010, 2 (1): 51-59

9.        Zhong-Zhong Zhao, Hua-Bing Zhang , Qian Chen, Zhao Xie, Ying-Yu Wang, Yi Yang, Ze-Zhou Wang , Jiang-Ling Li, Kai-Yuan Wu , Hong-Ning Wang, Min-Jie Meng , Rong Gao, Promotion of immunity of mice to Pasteurella multocida and Hog cholera vaccine by pig interleukin-6 gene and CpG motifs, Comparative Immunology, Microbiology & Infectious Diseases, 2009,32:191-205

10.    Zhigang Xu , Xiaoping Wan, Wei Zhang, Zheng Wang , Lin Cai , Ying Li, Qing Jiang, Rong Gao, Synthesis of biodegradable polycationic methoxy poly(ethylene glycol)–polyethylenimine–chitosan and its potential as gene carrier, Carbohydrate Polymers, 2009781):46-53

11.    Baofeng Song, Wei Zhang, Rong Peng , Jie Huang , Ting Nie, Ying Li, Qing Jiang, Rong Gao, Synthesis and cell activity of novel galactosylated chitosan as a gene carrier, Colloids and Surfaces B:Biointerfaces, 2009, 70:181-186

12.    Tao Zhang,Yuan Yuan Yu, Dong LiRong PengYing LiQing JiangPing DaiRong GaoSynthesis and properties of a novel methoxy poly(ethylene glycol)- modified galactosylated chitosan derivativeJ Mater Sci: Mater Med2009203: 673-680)

13.    Qian Chen, Zhong-Zhong Zhao, Rong Peng,Ying-Yu Wang, Zhao Xie, Ze-Zhou Wang, Rong Gao, Enhancement of immunity and resistance in mice by pig IL-6 gene and CpG motifs encapsulated in chitosan nanoparticleBiotechnology Journal , 2008, 3(2):264-273

14.    Zhao Xie , Hui Li, Jianlin Chen, Hua-bing Zhang, Qian Chen, Zhong-Zhong Zhao, Chi Cheng, Huan Zhang, Yi Yang, Rong Gao, Shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to Pasteurella multocida vaccine, Vaccine, 2007 25 8163–8171

15.    Huan Zhang, Chi Cheng, Min Zheng, Zhao Xie, Jiang Ling Li, Yi Yang, Yi Shen, Hong-Ning WangZezhou Wang, Rong Gao, Enhancement of immunity to an Escherichia coli. vaccine in mice orally inoculated with a fusion  gene encoding porcine interleukin 4 and 6, Vaccine, 2007, 25: 7094–7101

16.    Yi Yang, Jianlin Chen, Hui Li, Yingyi Wang, Zhao Xie, Huan Zhang, Cheng Chi, Hongning Wang, Rong Gao, Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine, Comparative Immunology, Microbiology & Infectious Diseases, 2007301:19-32

17.    Wu Kaiyuan, Wu Mei, Fu Manliang, Gao Rong, A novel CpG chitosan nanoparticles to regulate the cellular and humoral immunity of mice.  Biomedical and Environmental Sciences2006192):87-95

18.    Man-Liang FU, Sancheng Ying, Mei Wu, Hui Li, Rong Gao, Regulating effects of a novel CpG Chitosan-nanoparticles on immune responses to porcine paratyphoid vaccines in mice, Biomedical and Environmental Sciences2006194):315-322

19.    Hui Li, Shigui Liu, Lihuan Wang, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Tibet PigVeterinary Research communication, 2005, 29:395-405

20.    Mei Wu, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. Regulating effects of porcine interleukin-6 gene and CpG motifs on immune responses to porcine trivalent vaccines in mice. Res. Vet .Sci. 20047749-57

21.    Jinling Li, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 and CpG sequence. Veterinary Research Communication2004,28:33-46

22.    Mei WuLin ShuRong GaoShigui Liu et al, The Effect of Entrapment of Murine Interleukin 2 Gene with Chitosan Nanoparticles on the Expression and Its Regulation of Immune Response of Mice, Journal of biomedical engineering2004,6:947952

23.    Manliang Fu, Hui Li, Kaiyuan Wu, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Yak, Sichuan Journal of Zoology, 2005, 24:507-512r)

24.    Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, Immune response of mice to inoculation with TS11 antigenic gene of Taenia Solium, Chinese J. Veterinary Medicine, 2004,1:3-6

25.    Li HuiGao Rong*Wu Mei, Shigui Liu et alCloning and sequence analysis of γ-interferon gene from Tibet pig, Chinese Vet. Science and Technology, 2003,5:48-51

26.  Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, The eukaryotic expression of TS11 antigenic gene from cysticircus cellulosae, Chinese J.Vet. Medicine, 20034: 6-9

27.  Li HuiGao Rong*Wu meiDing Xiaotao, Shigui Liu et al, Cloning and Analyzing of  interleukin-4 cDNA from the lymphocyte of Tibet Pig, Chinese J. Immunology, 2003,6:475-478

28.  Long Zhangfu, Gao Rong, Men Mingjie, et al, Effect of porcine interleukin gene 6 entrapped with cationic liposome on the immune responses of mice inoculated with the antigenic gene vaccine of Taenia Solium, High Technology Letters, 2003.3:25-29

29.  Lv Xuebing, Li Jianglin, Gao Rong, et al, Effect of transgenic expression of  PIFN-γgene on the immune responses of mice immunization with paratyphoid vaccine, High technology letter,2003.4:236

30.  Ning Hong, Gao Rong, Qin Zhen, Shigui Liu et al, Analysis of the protein electrophoresis patterns of Curvularia lunata in maize and immunological detection of the pathogenic culture, High technology Communication2002.3:11-15

31.  Mei Wu, Rong Gao, Jiangling Li, Minjie Meng, Shigui Liu et al. Regulating Effect of CpG Motifs and Cationic Liposome on Immune Responses to Antigenic Gene of Taenia solium in Mice, High Technology Letters, 2002, 7: 39-44

32.    Jiangling Li, Rong Gao, Mei Wu , Mingjie Meng, Shigui Liu et al., The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of mice inoculated with the gene vaccine of Taenia solium of pig.  High Technology  Letters, 2002, 6: 26-30

33.    Wang Zezhou, Gao Rong, Yang Lin, Shigui Liu et al, Construction and Expression of fusion gene of somatostatin and Hepatitis B surface antigen gene in Yeast Pichia Pastoris, Journal of biomedical engineering (EI), 2002,3:483

34.    Meng Minjie, Gao Rong, Tang Manshu, Li Jiang, et al, Cloning and sequencing of porcine interleukin –6 gene from lymphocyte, J. Sichuan University ( natural science edition), 2002, 3:557-560

 

承担的主要科研项目

1.   科技部国际合作项目,猪瘟防控新疫苗免疫机理及其免疫调控研究

2.   European Commission SEVENTH FRAMEWORK PROGRAMME Grant agreement no.: 227003 CP-FP(欧盟国际合作项目),Improve tools and strategies for the prevention and control of classical swine fever

3.   四川省科技厅成果转化,新型动物抗感染免疫分子制剂研制和应用

4.   四川省科技厅重点科技项目,四川地方猪种免疫遗传资源发掘和利用

5.   国家863计划,家禽重要病毒病基因工程疫苗研究和创制;

6.   国家科技支撑计划,动物产品兽药残留安全控制技术研究;

7.   国家科技支撑计划,猪瘟及口蹄疫流行病学和快速诊断技术集成研究;

8.   国家重大项目前期基础研究,生物技术筛选高原植物活性分子及消除细菌耐药性的研究

9.   国家自然科学基金,猪白细胞介素-23基因克隆表达及其对猪免疫记忆的效应研究

10. 国家自然科学基金,猪新型免疫基因转体细胞表达的免疫调节效应;

11.    国家自然科学基金,猪白细胞介素2和6基因的改组研究;

12. 国家自然科学基金,鸡传染性贫血的免疫机理;

13. 国家自然科学基金,鸡马立克氏病及疫苗的免疫机理;

14. 四川省重点科技项目,猪高效分子免疫调节剂研究及应用;

15. 四川省重点科技项目,抗奶牛乳房炎新型抗菌肽基因分子制剂的研制;

16.    四川省重点科技攻关,动物高效营养分子代谢调节制剂的研制和应用;

17. 四川省重点科技项目,新型动物免疫基因制剂的研制和应用;

18. 四川省杰出青年科技基金,动物新型抗病融合基因的构建及应用研究

19. 四川省重点科技攻关,新型高效抗感染分子制剂的研究与开发;

20. 四川省重大科技项目,畜用DNA免疫增强剂研究及应用;

21. 国家教育部重点科技项目,畜用核酸免疫增强剂的基础及应用研究;

22. 四川省重点科技攻关,猪囊虫病防治关键技术研究;

23. 西藏自治区重大科技攻关项目,藏药及藏药材现代化新标准示范研究;

 

主要科研及工作获奖

1994:鸡传染性法氏囊病的免疫机理,省科技进步二等奖,省教委科技进步一等奖,

1996:鸡马立克氏病及其疫苗的免疫机理,省科技进步二等奖,省教委科技进步一等奖;

1997:小日龄火鸡新城疫免疫机理研究,省教委科技进步一等奖;

2000:囊虫病防治关键技术研究,省科技进步二等奖;

2010:猪用DNA分子免疫调节新技术研究,省科技进步二等奖;

2012年,猪鸡病原细菌耐药性研究及其在安全高效新兽药研制中的应用,国家科技进步二等奖

2004-2006:四川大学展虹奖研金二等奖;

2003-2005:四川大学青年骨干教师奖;

2003年:入选四川大学“214人才”计划第三层次人才;

2004年:入选“四川省杰出青年学科带头人培养计划;

2008年:四川省学术和技术带头人

 

 


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