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作者: user -- 发布时间:2016/6/10 20:18:35

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博士 教授 博导

职务:

中国生物化学与分子生物学会糖复合物专业委员会委员、常务委员
中国生物化学与分子生物学会生物化学与分子生物学教学专业委员会委员、常务委员
中国生物化学与分子生物学会农业生物化学分委会理事

中国生物工程学会糖工程专业委员会委员
国际凝集素委员会委员

联系方式:

办公电话:028-85415171   

电子邮件:baojinku@scu.edu.cn

学位简历:
1987.09-1991.07:浙江大学生物系生物化学与微生物学专业,本科
1991.09 –1994.07:四川大生物系生物化学专业,理学硕士
2000.09 –2003.12:四川大学生命科学学院,理学博士

工作简历:
1994.07–1996.07:四川大学生命科学学院,助教
1994.09 –1995.09:
在中国农科院植保所植物病虫害生物学国家重点实验室和中国农科院畜牧研究所客座研究
1996.07–1998.07:
四川大学生命科学学院,讲师
1998.07–2005.07:
四川大学生命科学学院副教授
2005.07-2006.07:
四川大学生命科学学院教授博士生导师
2006.07 –至今:
四川大学生命科学学院教授,博士生导师

个人科研工作简介
1
)研究方向及主要学术成果:
  立足我国丰富的天然药用资源宝库,围绕艾滋病等传染性疾病、临床常见恶性肿瘤等疾病及新药创制等国家战略需求,以具有特异糖结合能力的非免疫来源的凝集素为主线,集成现代生命科学技术方法,进行具有自主知识产权、抗病毒和抗肿瘤活性的凝集素等活性大分子的筛选、规模制备、基因克隆与蛋白序列、重组蛋白表达、生物活性及其基于肿瘤发生发展调控网络的分子机制、基于结构的分子设计和改造以及蛋白多肽数据库的构建和利用转基因植物大量获取活性蛋白等系统研究。发挥生命科学、医学和信息科学等学科特点及学科交叉优势,引入系统生物学整体性、信息化和网络调控的研究策略和理念,集成生物化学与分子生物学、细胞生物学、分子药理学、组学和系统生物学等技术方法,系统研究中草药蛋白多肽抗肿瘤分子机制及其潜在靶标,拓辟了“凝集素探针-肿瘤细胞程序性死亡相关蛋白-miRNA相互调控网络”研究新方向,为基于中药源活性蛋白多肽为先导或候选化合物的功能机制研究提供示范性的新思路并为源头创新药物研发提供通用模式。

2)科研项目:

国家自然科学基金项目:
1、寡糖链、氨基酸侧链基团与黄精凝集素生物学活性研究(批准号:39770178),1998 -2000,项目负责人
2、黄精凝集素结构与生物学活性关系研究(批准号:30000032),2001-2003,项目负责人
3、定点突变研究黄精凝集素II结构与功能关系(批准号:30270331),2003-2005,项目负责人
4、重组和突变抗艾滋病毒黄精凝集素II及其复合物晶体结构研究(批准号:30670469),2007-2009,项目负责人
5、黄精凝集素诱导肿瘤细胞自噬和凋亡的分子机制研究(批准号:30970643),2010-2012,项目负责人
6、凝集素诱导肿瘤细胞程序性死亡的分子机制(批准号:81173093),2012-2015, 项目负责人
7、高效低免疫原性黄精凝集素的分子设计(批准号: 81373311),2014-2017, 项目负责人  

8、十八届国际凝集素会议18th International Lectin Meeting, July, 1999, U.K),英国

9、第十九届国际凝集素会议(19th International Lectin Meeting, March, 2001, Brazil), 巴西

10、第二十届国际凝集素会议(20th International Lectin Meeting, May,2002,Denmark), 丹麦

11、第二十一届国际凝集素会议(21th International Lectin Meeting, May, 2004, Japan),日本

国家重大科技专项-转基因生物新品种培育:
“西南地区抗水稻胁迫因子基因克隆及功能验证”(2009ZX8009-072B)子课题负责人
国家高技术研究发展计划(863计划):
番茄营养品质改良的基因工程技术研究(2007AA10Z122),2007-2010,课题副组长

省部级课题:
1、中国农科院植物病虫害生物学国家重点实验室开放课题:葱莲凝集素的基因克隆,2002,项目负责人 
2、四川大学科技创新基金:传统中草药中具抗病毒活性的甘露糖结合蛋白的基因克隆与表达研究, 2004-2006,项目负责人 
3、四川省杰出青年科技基金:转植物凝集素基因培养抗虫新品种(批准号:06ZQ026-035),2006-2008,项目负责人 
4、四川省科技攻关项目:传统中草药中抗病毒抗肿瘤蛋白的分离、基因克隆表达及活性研究 (批准号:2006Z08-010),2006-2008,项目负责人 

3)发表论文:
2016

Lei Wu, Tao Liu, Yan Xiao, Xing Li, Yanan Zhu, YanZhao, Jinku Bao*, Chuanfang Wu, Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a -3p in human lung adenocarcinoma A549 cells, International Journal of Biological Macromolecules, 2016, 85:217–226

Wei Zhang, Jianzong Li, Haiyang Wang, Hao Luo, Xin Wang, Nan Zhou, Chuanfang Wu, Jinku Bao*, Computer-aided identification of potential TYK2 inhibitors from drug database, Journal of Molecular Structure, 2016, 309-317

Jian-zong Li, Hao Luo, Xin Wana, Dan-feng Liang, Kai-min Lu, Jin-ku Bao*, In silico identification of novel kinase inhibitors targeting HER2 from Natural Products for the treatment of HER2-positive breast cancer, International Journal of Molecular Sciences, 2016, In press

Tao Liu, Lei Wu, Di Wang, Haiyang Wang, Jinwu Chen, Chunlan Yang, Jinku Bao*, Chuanfang Wu, Role of reactive oxygen species mediated MAPK and NF-κB activation  in Polygonatum cyrtonema  lectin induced apoptosis and autophagy in human lung adenocarcinoma A549 cells, The Journal of Biochemistry, 2016, In press

Ya-nan Zhu, Li-kun Long, Yuan-yuan Li, Chuan-fang Wu, Jin-ku Bao*, Purification and Characterization of a Mannose-binding Lectin from the Allium macrostemon Bunge with apoptosis-inducing activity, Phytomedicine, 2016, In press 

2015

Zhining Wan, Xin Li, Rong Sun, Yuanyuan Li, Xiaoyun Wang , Xinru Li, Li Rong a, Zheng Shi, Jinku Bao*, Computer-assisted identification of novel small molecule inhibitors targeting GLUT1, Journal of Molecular Structure, 2015, 1101: 57-65

Jing Li, Nan Zhou, Wen Liu, Jianzong Li, Yu Feng, Xiaoyun Wang, Chuanfang, Wu, Jinku Bao*, Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches, Journal of Biomolecular Structure and Dynamics, 2015, DOI: 10.1080/07391102.2015.1070749

Zi-jie Wang, Zhi-ning Wan, Xu-dong Chen, Chuan-fang Wu, Guo-long Gao,Rong Liu, Zheng Shi, Jin-ku Bao*, In silico identification of novel kinase inhibitors by targeting B-Raf from natural products database, J Mol Model, 2015, 21:102

Rong Sun, Xin Li, Yuanyuan Li, Xun Zhang, Xinru Li, Xiaoyu Li, Zheng Shi, Jinku Bao*, Screening of novel inhibitors targeting lactate dehydrogenase A via four molecular docking strategies and dynamics simulations, J Mol Model, 2015,21: 133

Jianzong Li , Yu Feng , Xiaoyun Wang , Jing Li , Wen Liu , Li Rong and Jinku Bao*, An Overview of Predictors for Intrinsically Disordered Proteins over 2010–2014,  Int. J. Mol. Sci. 2015, 16, 23446-23462

 

2014

Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J*, Wang Y: Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PloS one 2014, 9(7):e101526-e101526.

Li X, Sun R, Chen W, Lu B, Li X, Wang Z, Bao J*: A Systematic In Silico Mining of the Mechanistic Implications and Therapeutic Potentials of Estrogen Receptor (ER)-alpha in Breast Cancer. Plos One 2014, 9(3).

Yu Y, Deng Y, Lu B-m, Liu Y-x, Li J, Bao J-k* : Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis 2014, 19(1):1-18.

Xu H-l, Wang Z-j, Liang X-m, Li X, Shi Z, Zhou N, Bao J-k*: In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs. Molecular Biosystems 2014, 10(6):1524-1537.

Fu LL, Liu J, Chen Y, Wang FT, Wen X, Liu HQ, Wang MY, Ouyang L, Huang J, Bao JK* et al: In silico analysis and experimental validation of azelastine hydrochloride (N4) targeting sodium taurocholate co-transporting polypeptide (NTCP) in HBV therapy. Cell Proliferation 2014, 47(4):326-335. 

Wu L, Zhou N, Sun R, Chen XD, Feng SC, Zhang B, Bao JK*: Network-based identification of key proteins involved in apoptosis and cell cycle regulation. Cell Proliferation 2014, 47(4):356-368.

Shi Z, An N, Lu BM, Zhou N, Yang SL, Zhang B, Li CY, Wang ZJ, Wang F, Wu CF, Bao JK*: Identification of novel kinase inhibitors by targeting a kinase-related apoptotic protein-protein interaction network in HeLa cells. Cell Proliferation 2014, 47(3):219-230.

Wang H-L, Li C-Y, Zhang B, Liu Y-D, Lu B-M, Shi Z, An N, Zhao L-K, Zhang J-J, Bao J-K* : Mangiferin Facilitates Islet Regeneration and beta-Cell Proliferation through Upregulation of Cell Cycle and beta-Cell Regeneration Regulators. International Journal of Molecular Sciences 2014, 15(5):9016-9035.

Shi Z, Chen J, Li C-y, An N, Wang Z-j, Yang S-l, Huang K-f, Bao J-k*: Antitumor effects of concanavalin A and Sophora flavescens lectin in vitro and in vivo. Acta Pharmacologica Sinica 2014, 35(2):248-256.

Bangmin Lu , Bin Zhang, Wei Qi, Yanan Zhu, Yan Zhao, Nan Zhou, Rong Sun, Jinku Bao*, and Chuanfang Wu, Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin, Acta Biochim Biophys Sin 2014, 46: 923–934.

Zhou N, Zhang Y, Zhang J-C, Feng L, Bao J-K*: The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development. Journal of the Formosan Medical Association 2014, 113(3):143-147.

Jing Li , Nan Zhou , Kun Luo , Wei Zhang , Xinru Li , Chuanfang Wu Jinku Bao*:In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis TherapyInternational Journal of Molecular Sciences 2014, 15(9):15994-16011.

Xu G-B, Yang T, Bao J-K*, Fang D-M, Li G-Y: Isochaetomium A(2), a new bis(naphthodihydropyran-4-one) with antimicrobial and immunological activities from fungus Chaetomium microcephalum. Archives of Pharmacal Research 2014, 37(5):575-579. 

Xu G-B, Wang N-N, Bao J-K*, Yang T, Li G-Y: New Orsellinic Acid Esters from Fungus Chaetomium globosporum. Helvetica Chimica Acta 2014, 97(1):151-159. 

 

2013

Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J* et al: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 2013, 500(7461):227

Shi Z, Li C-y, Zhao S, Yu Y, An N, Liu Y-x, Wu C-f, Yue B-s, Bao J-k*: A systems biology analysis of autophagy in cancer therapy. Cancer Letters 2013, 337(2):149-160.  

Lin Y, Wang F, Yang L-j, Chun Z, Bao J-k*, Zhang G-l: Anti-inflammatory phenanthrene derivatives from stems of  Dendrobium denneanum. Phytochemistry 2013, 95:242-251.

Fu LL, Yang Y, Xu HL, Cheng Y, Wen X, Ouyang L, Bao JK*, Wei YQ, Liu B: Identification of novel caspase/autophagy-related gene switch to cell fate decisions in breast cancers. Cell Proliferation 2013, 46(1):67-75. 

Shi Z, An N, Zhao S, Li X, Bao JK*, Yue BS: In silico analysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells. Cell Proliferation 2013, 46(1):86-96.

Li CY, Wang Y, Wang HL, Shi Z, An N, Liu YX, Liu Y, Zhang J, Bao JK*, Deng SP: Molecular mechanisms of Lycoris aurea agglutinin-induced apoptosis and G2/M cell cycle arrest in human lung adenocarcinoma A549 cells, both in vitro and in vivo. Cell Proliferation 2013, 46(3):272-282.

Li X, Xu H-l, Liu Y-x, An N, Zhao S, Bao J-k*: Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacologica Sinica 2013, 34(5):612-624.  

Wu L, Bao J-k*: Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)- related lectins. Glycoconjugate Journal 2013, 30(3):269-279.  

Pu X, Qu X, Chen F, Bao J*, Zhang G, Luo Y: Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Applied Microbiology and Biotechnology 2013, 97(21):9365-9375.

Shi Z, Wang Z-j, Xu H-l, Tian Y, Li X, Bao J-k*, Sun S-r, Yue B-s: Modeling, docking and dynamics simulations of a non-specific lipid transfer protein from Peganum harmala L. Computational Biology and Chemistry 2013, 47:56-65.

Zhou N, Zhang J, Feng L, Lu B, Wang Z, Sun R, Wu C, Bao J*: IntApop: A web service for predicting apoptotic protein interactions in humans. Biosystems 2013, 114(3):238-244.  

Liu B, Bao J-K*, Yang J-M, Cheng Y: Targeting autophagic pathways for cancer drug discovery. Chinese Journal of Cancer 2013, 32(3):113-120.  

Gao F, Bao J*: Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2013, 69:861-863.

Gao F, Bao J*: Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2013, 69:643-645.  

Lv J, Wang Z, Zhang L, Wang H-L, Liu Y, Li C, Deng J, Yi W, Bao J-K*: Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo. Journal of Animal and Veterinary Advances 2013, 12(3):352-359.  

 

2012

Li W-w, Li J, Bao J-k*: Microautophagy: lesser-known self-eating. Cellular and Molecular Life Sciences 2012, 69(7):1125-1136. 

Fu L-L, Wen X, Bao J-k*, Liu B: MicroRNA-modulated autophagic signaling networks in cancer. International Journal of Biochemistry & Cell Biology 2012, 44(5):733-736.

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK*: Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Proliferation 2012, 45(6):487-498. 

Fu LL, Zhao X, Xu HL, Wen X, Wang SY, Liu B, Bao JK*, Wei YQ: Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death. Cell Proliferation 2012, 45(5):477-485.

Wang Y, Liu Y, Wang H, Li C, Qi P, Bao J*: Agaricus bisporus lectins mediates islet beta-cell proliferation through regulation of cell cycle proteins. Experimental Biology and Medicine 2012, 237(3):287-296. 

Wang Y, Wang H, Liu Y, Li C, Qi P, Bao J*: Antihyperglycemic Effect of Ginsenoside Rh2 by Inducing Islet beta-cell Regeneration in Mice. Hormone and Metabolic Research 2012, 44(1):33-40. 

Xu H-l, Li C-y, He X-m, Niu K-q, Peng H, Li W-w, Zhou C-c, Bao J-k*: Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1). Journal of Molecular Modeling 2012, 18(1):27-37.

Wang N, Xu H-l, Zhao X, Wen X, Wang F-t, Wang S-y, Fu L-l, Liu B, Bao J-k*: Network-Based Identification of Novel Connections Among Apoptotic Signaling Pathways in Cancer. Applied Biochemistry and Biotechnology 2012, 167(3):621-631.

 

2011
 Liu JJ, Lin M, Yu JY, Liu B*, Bao JK*. Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Letters. 2011. 300(2):105-114.

 Wang SY, Yu QJ, Bao JK*, Liu B. Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways. Biochemical and Biophysical Research Communications. 2011. 406(4):497-500.

 Li WW, Yu JY, Xu HL, Bao JK*. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochemical and Biophysical Research Communications. 2011. 414(2):282-286. 

 Li CY, Luo P, Liu JJ, Wang EQ, Li WW, Ding ZH, Mou L, Bao JK*. Recombinant expression of Polygonatum cyrtonema lectin with anti-viral, apoptosis-inducing activities and preliminary crystallization. Process Biochemistry. 2011. 46(2): 533-542.

Li CY, Wang EQ, Cheng Y, Bao JK*. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer theraputics. The International Journal of Biochemistry & Cell Biology. 2011. 43(5):701-704.

Fu LL, Zhou CC, Yao S, Yu JY, Liu B, Bao JK*. Plant lectins: targeting programmed cell death pathways as antitumor agents. The International Journal of Biochemistry & Cell Biology. 2011. 43(10):1442-1449.

Yang Y, Xu HL, Zhang ZT, Liu JJ, Li WW, Ming H, Bao JK*. Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities. Phytomedicine. 2011, 18(8-9):748-755.

He XM, Ji N, Xiang XC, Luo P, Bao JK*. Purification, characterization, and molecular cloning of a novel antifungal lectin from the roots of Ophioglossum pedunculosum. Applied Biochemistry and Biotechnology. 2011. 165(7-8):1458-1472.

Yu QJ, Li ZY, Yao S, Ming M, Wang SY, Liu B, Bao JK*. In silico analysis of molecular mechanisms of Galanthus nivalis agglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis. Applied Biochemistry and Biotechnology. 2011. 165(3-4):1037-1046.

 Zhang F, Li CY, Wang EQ, Li WW, Yu QJ, Wen X, Liu JJ, Bao JK*. The Global Component-Target Network in Panax Ginseng C. Letters in Drug Design & Discovery, 2011, 8, 181-188. 

 

2010
 Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK*. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. Biochimie. 2010. 92(12):1934-1938.

 Liu B, Bian HJ, Bao JK*. Plant lectins: Potential antineoplastic drugs from bench to clinic. Cancer Letters. 2010. 287(1):1-12.

 Yao Q, Wu CF, Luo P, Xiang XC, Liu JJ, Mou L, Bao JK*. A new chitin-binding lectin from rhizome of Setcreasea purpurea with antifungal, antiviral and apoptosis-inducing activities. Process Biochemistry. 2010. 45(9): 1477-1485.

 Zhang ZT, Peng H, Li CY, Liu JJ, Zhou TT, Yan YF, Li Y, Bao JK*. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine. 2010. 18(1):25-31.

Li CY, Xu HL, Liu B, Bao JK*. Concanavalin A, from an old protein to novel candidate antineoplastic drug. Current Molecular Pharmacology. 2010. 3(3):123-128. 

 Liu B, Cheng Y, Liu Q, Bao JK*, Yang JM. Autophagic pathways as new targets for cancer drug development. Acta Pharmacologica Sinica. 2010. 31(9):1154-64.

Ding J, Bao J*, Zhu D, Zhang Y, Wang DC. Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure. Journal of Structural Biology. 2010. 171(3):309-17.

 

2009

 Liu B, Min MW, Bao JK*. Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells. Autophagy, 2009. 5(3): 432-433.

 Liu B, Cheng Y, Bian HJ, Bao JK*. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy. 2009. 5(2):253-255.

Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK*. Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Letters. 2009. 275(1):54-60.

 Liu B, Li CY, Bian HJ, Min MW, Chen LF, Bao JK*. Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells. Archives of Biochemistry and Biophysics. 2009. 482(1-2):1-6

 Liu B, Zhang B, Min MW, Bian HJ, Chen LF, Liu Q, Bao JK*. Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells. Biochimica et Biophysica Acta (BBA) - General Subjects. 2009. 1790(8):840-844.

 Peng H, Lv H, Wang Y, Liu YH, Li CY, Meng L, Chen F, Bao JK*. Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities. Peptides. 2009. 30(10):1805-1815.

 Lv H, Kong Y, Yao Q, Zhang B, Leng FW, Bian HJ, Balzarini J, Van Damme E, Bao JK*. Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 activities. Phytomedicine. 2009. 16(2-3):198-205.

Chen J, Liu B, Ji N, Zhou J, Bian HJ, Li CY, Chen F, Bao JK*. A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities. Phytomedicine. 2009. 16(4):352-360.

 Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, Bao JK*. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine. 2009. 16(6-7):601-608.

Ye SH, Chen S, Zhang F, Wang W, Tian Q, Liu JZ, Chen F, Bao JK*. Transgenic tobacco expressing Zephyranthes grandiflora agglutinin confers enhanced resistance to aphids. Applied Biochemistry and Biotechnology. 2009. 158(3):615-30.

Li CY, Wang Y, Peng H, Bian HJ, Min MW, Chen LF, Liu Q, Bao JK*. In silico Analysis of the Potential Infection Mechanisms of Magnaporthe grisea from Horizontal Gene Transfer Hypothesis. Genomics, Proteomics & Bioinformatics. 2009. 7(3):77-86. 
 Li CY, Meng L, Liu B, Bao JK*. Galanthus nivalis agglutinin (GNA)-related lectins: Traditional proteins, Burgeoning drugs? Current Chemical Biology. 2009. 3:324-333.

 Zhao Q, Wu CF, Wang WG, Yuan S, Bao JK*, Chen F. In vitro plantlet regeneration system from rhizomes and mannose-binding lectin analysis of Polygonatum cyrtonema Hua. Plant Cell, Tissue and Organ Culture. 2009. 99(3): 269-275.

 

2008

 Liu B, Xu XC, Cheng Y, Huang J, Liu YH, Liu Z, Min MW, Bian HJ, Chen J, Bao JK*. Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites. BMB Reports. 2008. 41(5):369-375.

 Liu C, Zhao X, Xu XC, Li LR, Liu YH, Zhong SD, Bao JK*. Hemagglutinating activity and conformation of a lactose-binding lectin from mushroom Agrocybe cylindracea. International Journal of Biological Macromolecules. 2008. 42(2):138-144.

 Liu Z, Liu B, Zhang ZT, Zhou TT, Bian HJ, Min MW, Liu YH, Chen J, Bao JK*. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine. 2008. 15(10):867-875.

 Tian Q, Wang W, Miao C, Peng H, Liu B, Leng FW, Dai L, Chen F, Bao JK*. Purification, characterization and molecular cloning of a novel mannose-binding lectin from rhizomes of Ophiopogon japonicus with antiviral and antifungal activities. Plant Science. 2008. 175(6): 877-884.

 Xu XC, Zhong SD, Kai F, Li LR, Liu C, Liu B, Bao JK*. Preparation and characterization of a novel recombinant human parathyroid hormone (1-34) analog (Gly1-Gln26-rhPTH(1-34)) with enhanced biological activity. Protein & Peptide Letters. 2008. 15(8):854-860.

 Ding JJ, Bao JK, Zhu DY, Zhang Y, Wang DC. Crystallization and Preliminary X-Ray Diffraction Analysis of a Novel Mannose-Binding Lectin with Antiretroviral Properties from Polygonatum cyrtonema Hua. Protein and Peptide Letters. 2008. 15(4):411-414.

 

2007

 Luo YT, Xu XC, Liu JW, Li J, Sun YS, Liu Z, Liu JZ, Van Damme E, Balzarini J, Bao JK*. A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines. Journal of Biochemistry and Molecular Biology. 2007. 40(3):358-367.  

 Liu JW, Xu XC, Liu JZ, Balzarini J, Luo YT, Kong Y, Li J, Chen F, Van Damme E, Bao JK*. A novel tetrameric lectin from Lycoris aurea with four mannose-binding sites permonomer. Acta Biochimica Polonica. 2007. 54(1):159-166.  

 Xu XC, Wu CF, Liu C, Luo YT, Li J, Zhao XP, Damme EV, Bao JK*. Purification and Characterization of a Mannose-Binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity. Acta Biochimica et Biophysica Sinica (Shanghai). 2007. 39(7): 507-519  

学术专著
1. Jin-Ku Bao. Autophagy pathways and drug targets in cancer. In: Autophagy: Principles, Regulation and Roles in Disease.  2011. Nova Science Publisher. Hauppauge NY, USA

2.
鲍锦库,《自噬:生物学与疾病》第二十八章:针对自噬的药物开发和治疗的展望。科学出版社(2015,第二版)。

其它论著
 An J, Liu JZ, Wu CF, Li J, Dai L, Van Damme E, Balzarini J, De Clercq E, Chen F, Bao JK*. Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua. Acta Biochimica et Biophysica Sinica (Shanghai). 2006. 38(2):70-8.
 Wu CF, Li J, An J, Chang LQ, Chen F, Bao JK*. Purification, Biological Activities, and Molecular Cloning of a Novel Mannose-Binding Lectin from Bulbs of Zephyranthes candida Herb (Amaryllidaceae). Journal of Integrative Plant Biology. 2006. 48(2):223-231.

Gao S, An J, Wu CF, Gu Y, Chen F, Yu Y, Wu QQ, Bao JK*. Effect of amino acid residue and oligosaccharide chain chemical modifications on spectral and hemagglutinating activity of Millettia dielsiana Harms. ex Diels. Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2005. 37(1): 47-54.

 Gong M, An J, Lü HZ, Wu CF, Li YJ, Cheng JQ, Bao JK*. Effects of denaturation and amino acid modification on fluorescence spectrum and hemagglutinating activity of Hericium erinaceum Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2004. 36(5):343-350

 Wu CF, An J, He XJ, Deng J, Hong ZX, Liu Chao, Lu HZ, Li YJ, Wang CJ, Chen F, Bao JK*. Molecular Cloning of a Novel Mannose-binding Lectin Gene from Bulbs of Amaryllis vittata (Amaryllidaceae). Acta Botanica Sinica. 2004. 46(11):1301-1306.
 Jiang FB, Du J, Yu XQ, Bao JK, Zeng XC. Metallomicellar catalysis: accelerated hydrolysis of BNPP by copper(II), zinc(II), and nickel(II) complexes of long alkanol-imidazole in CTAB micellar solution. Journal of Colloid and Interface Science. 2004. 273(2):497-504.

 Cai YF, Zhang H, Zeng Y, Mo JC, Bao JK, Miao C, Bai J, Yan F, Chen F. An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton. Journal of Biosciences. 2004. 29(1):67-71.

 Biological Activity Analysis of Polygonatum  cyrtonema Hua. Lectin by Site-Directed Mutagenesis, Trends in Glycoscience and Glycotechnology, 2004,16:pp.s1s32

 In Vitro Plantlet Regeneration from Rhizome Lumps and Mannose-Binding Lectin Analysis of Polygonatum cyrtonema Hua.(Family Liliaceae) ,Trends in Glycoscience and Glycotechnology(TIGG), 2004,16: pp.S 33S 64IF 0.863
 Miao C, Gou XP, Lan LQ, Bao JK, Xu Y, Wang SH, Chen F. Molecular cloning and expression of RSSSG58 gene in rice sperm cells. Acta Botanica Sinica. 2003. 45(2):234-241.
 Xiang QX, Zhou H, Wang XY, Yu XQ, Bao JK, Xie RG. Interaction between Bifunctional Kioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System. Chinese Chemical Letters. 2002. 13(3):223-226.

 Bao JK, Zeng ZK. Purification and biological activity of a lectin from Polygonatum cyrtonema Hua. Eur J Cell Biol 1997, 74(Suppl.46): 8.

 Bao JK, Zhou H, Zeng ZK. Conformation and activity of Millettia dielsianna Harms lectin, Eur J Cell Biol,1997,74(Suppl.46):8

国家发明专利:
1
、一种大量获得黄精凝集素II的方法。专利号:ZL 2004 1 0021659.1
2
、黄精凝集素Ⅱ蛋白在制备治疗或预防乙型肝炎的药中的应用。专利号:ZL 2004 1 0022354.2
3
、黄精凝集素II蛋白在制备治疗或预防单纯疱疹病毒所致疾病的药中的应用。专利号:ZL 2004 1 0022353.8
4
、黄精凝集素II蛋白在制备治疗或预防艾滋病的药中的应用。专利号:ZL 2006 1 0005577.7

5、羊耳兰凝集素蛋白、基因及其应用。专利号:ZL 2011 1 0023616.7

6、抗HIV药物安瑞那韦在制备抗肿瘤药物中的应用,ZL 2013 10532562.6


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