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李成华
作者: user -- 发布时间:2016/6/10 20:49:31

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李成华,博士,副教授

联系方式: 028-85418843 lichenghua_AT_scu.edu.cn(请把_AT_换成@ 

学习及工作经历

2014.10至今: 四川大学生命科学学院生长代谢与衰老研究中心,副教授

2013.10-2014.10: 美国杜克大学医学院,访问学者

2012.7-2013.10: 四川大学生命科学学院生长代谢与衰老研究中心,副教授

2010.8-2012.6: 四川大学生命科学学院生长代谢与衰老研究中心,讲师

2006.9-2010.7: 清华大学生命科学学院,博士

2003.8-2006.8: 重庆医科大学基础医学院,助教、讲师

2000.9-2003.7: 中南大学湘雅医学院医学遗传学国家重点实验室,硕士

1996.9-2000.7: 兰州大学生命科学学院,学士

 

研究方向及兴趣

1. 肿瘤发生:利用哺乳动物细胞和小鼠作为模式生物,主要研究p63蛋白及其调控因子在肿瘤发生、发展中的作用

2. 金属代谢:利用酵母和哺乳动物细胞作为模式生物,研究铜、铁、锌等金属元素在细胞内代谢调控的分子机理

 

近年来发表的主要论文

1. Anning Han, Juan Li, Yimin Li, Yang Wang, Johann Bergholz, Yujun Zhang, Chenghua Li*, Zhi-Xiong Xiao*. p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget, 2016, in press. (* Corresponding author) 

2. Chen J, Shi H, Qi J, Liu D, Yang Z, Li C*. JNK1 inhibits transcriptional and pro-apoptotic activity of TAp63γ. FEBS Lett. 2015, 589(23):3686-90. (* Corresponding author)

3. Li D#, Li C#, Wu M, Chen Q, Wang Q, Ren J, Zhang Y.PKCδ stabilizes TAp63 to promote cell apoptosis. FEBS Lett. 2015, 589(16):2094-9. (# Co-first author)

4. Chenghua Li, Zhi-Xiong Xiao. Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway. BioMed Res Int, vol. 2014, 2014: 175721.

5. C Li*, DL Chang, Z Yang, J Qi, R Liu, H He, D Li, ZX Xiao*. Pin1 modulates p63a protein stability in regulation of cell survival, proliferation and tumor formation. Cell Death and Disease, 2013, 4: e943. (* Corresponding author)

6. Qiongqiong Chen, Decai Li, Jian Ren, Chenghua Li*, Zhi-Xiong Xiao. MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. Biochemical and Biophysical Research Communications. 2013440(1)179-183. * Corresponding author

7. Lihua Liu, Jin Qi, Zemin Yang, Lianghong Peng, Chenghua Li*. Low-affinity copper transporter CTR2 is regulated by copper-sensing transrciption factor Mac1p in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications. 2012420(3)600-604. * Corresponding author

8. Jin Qi, Anning Han, Zemin Yang, Chenghua Li*. Metal-sensing transrciption factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications. 2012, 423(2): 424-8.* Corresponding author

9. Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li*, Yujun  Zhang*. DNA damage down-regulates DNp63a and induces apoptosis independent of wild type p53. Biochemical and Biophysical Research Communications. 2012, 423(2): 338-43. * Corresponding author

10. Chenghua Li, Juan Wang, Bing Zhou. The Metal Chelating and Chaperoning Effects of ClioquinolInsights from Yeast Studies. Journal of Alzheimer’s Disease, 2010214: 1249–1262.

 

 

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