李娟 博士、教授、博士生导师
联系方式：办公室电话：028-85415025
电子邮件：lijuanscuhk@163.com
一、学习与工作简历
1990-1994：四川大学，理学学士
1994-1997：四川大学，理学硕士
1997-1999：成都生物制品研究所，实习研究员
1999-2003：香港大学动物学系，理学博士
2004-2006：香港大学动物学系, 博士后
2006-现在：四川大学生命科学学院讲师，副教授，教授
二、主要研究内容
1、家鸡卵泡发育进程中重要基因功能鉴定与表达调控机制解析
2、肠道微生物代谢产物对动物生长发育的影响
三、项目支持：
国家自然科学基金；四川省应用基础研究基金；成都市应用基础研究基金等。
四、学术兼职：
担任SCI杂志《Frontiers in Physiology》(IF=4.566) - Avian Physiology方向副主编(Associate Editor)
代表性论文：
1. Jiang B, Cao B, Zhou Z, Li Z, Lv C, Zhang J, Zhang H, Wang Y, Li J.* (2022) Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development. Genes, 13(7), 1113. (*通讯) (IF = 4.096)
2. Zhang J.#, Lv C.#, Mo C., Liu M., Wan Y., Li J.* & Wang Y.* (2021) Single-Cell RNA Sequencing Analysis of Chicken Anterior Pituitary: A Bird’s-Eye View on Vertebrate Pituitary. Frontiers in Physiology, 12, 1-21. (*通讯) (IF = 4.566)
3. Zhu, G., Fang, C., Mo, C., Wang, Y., Huang, Y.*, & Li, J.* (2021). Transcriptomic analysis of granulosa cell populations proximal and distal to the germinal disc of chicken preovulatory follicles. Scientific reports, 11(1), 1-14. (*通讯) (IF = 3.998)
4. Cui, L., Lv, C., Zhang, J., Li, J.*, & Wang, Y.* (2020). Characterization of Four Urotensin II Receptors (UTS2Rs) in Chickens. Peptides, 138, 170482. (*通讯) (IF = 2.843)
5. Zhang, J., Li, J., Wu, C., Hu, Z., An, L., Wan, Y., Fang, C., Zhang X., Li, J.*, & Wang, Y.* (2020). The Asp298Asn polymorphism of melanocortin‐4 receptor (MC4R) in pigs: evidence for its potential effects on MC4R constitutive activity and cell surface expression. Animal Genetics, 51(5), 694-706. (*通讯) (IF = 2.841)
6. Li, X., Li, Z., Deng, Y., Zhang, J., Li, J.*, & Wang, Y.* (2020). Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens. Poultry science, 99(3), 1643-1654. (*通讯) (IF = 2.659)
7. Chen, J., Huang, S., Zhang, J., Li, J.*, & Wang, Y.* (2020). Characterization of the neuropeptide FF (NPFF) gene in chickens: evidence for a single bioactive NPAF peptide encoded by the NPFF gene in birds. Domestic animal endocrinology, 72, 106435. (*通讯) (IF = 1.778)
8. Zhu, G., Fang, C., Li, J., Mo, C., Wang, Y., & Li, J.* (2019). Transcriptomic diversification of granulosa cells during follicular development in chicken. Scientific reports, 9(1), 1-16. (*通讯) (IF = 4.381)
9. Liu H.K., Luo Q., Zhang J.N., Mo C.H., Wang Y. & Li J.* (2019) Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution. General and comparative endocrinology 283, 113231. (*通讯) (IF = 2.445)
10. Zhang J#, Zhou Y, Wu C, Wan Y, Fang C, Li J, Fang W, Yi R, Zhu G, Li J*, Wang Y* (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in Endocrinology, 9:756. (IF = 3.519，*通讯作者)
11. Zhang J#, Wan Y#, Fang C, Chen J, Ouyang W, Li J*, Wang Y (2018) The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates. Biochemical and biophysical research communications, 501(2):408-414. (IF = 2.559，*通讯作者)
12. Wan Y#, Zhang J#, Fang C, Chen J, Li J, Li J*, Wu C, Wang Y* (2018) Characterization of neuromedin U (NMU), neuromedin S (NMS) and their receptors (NMUR1, NMUR2) in chickens. Peptides, 101:69-81. (IF = 2.851，*通讯作者)
13. Lv C#, Mo C, Liu H, Wu C, Li Z, Li J*, Wang Y* (2018) Dopamine D2-like receptors (DRD2 and DRD4) in chickens: Tissue distribution, functional analysis, and their involvement in dopamine inhibition of pituitary prolactin expression. Gene, 651:33-43. (IF = 2.498，*通讯作者)
14. Zhang J#, Li X, Zhou Y, Cui L, Li J, Wu C, Wan Y, Li J*, Wang Y* (2017) The interaction of MC3R and MC4R with MRAP2, ACTH, alpha-MSH and AgRP in chickens. The Journal of endocrinology, 234(2):155-174. (IF = 4.706，*通讯作者)
15. Mo C#, Huang L, Cui L, Lv C, Lin D, Song L, Zhu G, Li J*, Wang Y* (2017) Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. J Mol Endocrinol, 59(1):61-79. (IF = 3.577，*通讯作者)
16. Gao S#, Zhang J#, He C, Meng F, Bu G, Zhu G, Li J, Wang Y* (2017) Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens. General and comparative endocrinology, 240:46-60. (IF = 2.585)
17. Cui L#, Lv C, Zhang J, Mo C, Lin D, Li J, Wang Y* (2017) Characterization of melanin-concentrating hormone (MCH) and its receptor in chickens: Tissue expression, functional analysis, and fasting-induced up-regulation of hypothalamic MCH expression. Gene, 615:57-67. (IF = 2.415)
18. He C#, Zhang J#, Gao S, Meng F, Bu G, Li J, Wang Y* (2016) Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis. General and comparative endocrinology, 236:24-34. (IF = 2.667)
19. Bu G#, Lin D, Cui L, Huang L, Lv C, Huang S, Wan Y, Fang C, Li J, Wang Y* (2016) Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion. Endocrinology. 157(9):3562-3576. (IF = 4.286)
20. Mo C#, Cai G, Huang L, Deng Q, Lin D, Cui L, Wang Y, Li Juan* (2015) Corticotropin-releasing Hormone (CRH) Stimulates Cocaine- and amphetamine-regulated Transcript Gene (CART1) Expression through CRH Type 1 Receptor (CRHR1) in Chicken Anterior Pituitary. Mol Cell Endocrinol. 2015 pii: S0303-7207(15)30073-3. (IF = 3.859，*通讯作者)
21. Cai G#, Mo C#, Huang L, Li Juan*, Wang Y*(2015) Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus). PLoS One. May 18;10(5):e0127107. (IF = 3.057，*通讯作者)
22. Li X#, Fang W, Hu Y, Wang Y, Li Juan* (2015) Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Gene. Oct 10;570(2):221-9. (IF = 2.0，*通讯作者)
23. Zhang J#, Cheng S, Wang Y, Yu X, Li Juan* (2014) Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species. Domestic Animal Endocrinology 47:108-118 (IF = 2.377) (*通讯作者)
24. Meng F#, Huang G, Gao S, Li Juan, Yan Z, Wang Y* (2014) Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1–27NH2-induced growth hormone secretion in cultured chicken pituitary cells. Molecular and Cellular Endocrinology 384: 83-95. (IF = 4.039) (*通讯作者)
25. Mo C#, Zhong Y, Wang Y, Yan Z, Li Juan* (2014) Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine. Domestic Animal Endocrinology 48:1-6 (IF =2.377) (*通讯作者)
26. He X#, Meng F, Wang Y, Li Juan* (2014) Molecular Cloning and Characterization of Two Pig Vasoactive Intestinal Polypeptide Receptors (VPAC1-R and VPAC2-R). DNA Cell Biol. 33:259-270 (IF = 2.344) (*通讯作者)
27. Li Juan#*, Meng F, Song C, Wang Y, Leung FC* (2012) Characterization of chicken visfatin gene: cDNA cloning, Tissue expression, and promoter analysis. Poultry Science 91: 2885-94 (IF = 1.728) (*通讯作者)
28. Huang G#, Li Juan*, Fu H, Yan Z, Bu G, He X, Wang Y* (2012) Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology 43: 1-15 (IF = 2.377) (*通讯作者)
29. Wang Y#, Huang G, Li Juan, Meng F, He X. Leung F.C* (2012) Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280 (IF = 4.118)
30. yao Meng#, Shuangfeng Liu, Juan Li, Yanfa Meng, Xiaojun Zhao* (2012) Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol Int J Nanomedicine. 2012; 7: 3133–3142. (IF = 4.118)
31. Wang Y#, Li Juan, Kwok AHY, Ge W & Lueng FC (2010) A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative endocrinology 166: 200-210. (IF = 2.732)
32. Wang Y#, Li Juan, C. Wang CY, Kwok AHY, Zhang X & Leung FC (2010) Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31. (IF = 1.896)
33. Wang J#, Wang Y, Li X, Li Juan* and Leung FC* (2008) Cloning, tissue distribution and functional characterization of chicken glucagon receptor. Poultry Science 87：2678-2688 (IF = 1.603) (*通讯作者)
34. Wang Y#, Li Juan, Wang CY, Kwok AHY, Leung FC. (2007) Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416 (IF=5.045)
35. Wang Y#, Li Juan，Wang CY, Kwok AHY, Leung FC (2007) Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440. (IF=5.045)
36. Wang Y#, Wang Z, Li Juan, Wang Y*, Leung FC* (2007) A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, (IF =3.498)
37. Li Juan#, Wang X, and Leung FC* (2007) The intragenomic polymorphism of a partially inverted repeat (PIR) in Gallus gallus domesticus, potential role of inverted repeats in satellite DNAs evolution. Gene 387:118-125. (IF = 2.871)
38. Li Juan# and Leung FC * (2006) A CR1 element is embedded in a novel tandem repeat (HinfI repeat) within the chicken genome. Genome 49:97-103. (IF = 1.785)
39. Wang CY#, Wang Y, Li Juan and Leung FC* (2006) Expression profiles of growth hormone-releasing hormone and growth hormone-releasing hormone receptor during chicken embryonic pituitary development. Poultry Science 85:569-576. (IF = 1.603)
40. Wang X#, Li Juan and Leung FC* (2002) Partially inverted tandem repeat isolated from pericentric region of chicken chromosome 8. Chromosome Res 10:73-82. (IF = 3.469)
获 奖
1. 第七届大学生《挑战杯》课外学术活动竞赛：代表香港大学获特等奖
2. 四川大学青年骨干教师奖
3. 《精品开放课程建设突出贡献奖》（细胞生物学课程组，排名第三）
本课题组招收硕士/博士/博士后，欢迎感兴趣的同学联系。
