李中瀚

教授， 博士生导师

联系方式：

Email: Zhonghan.Li@Scu.edu.cn

地址： 四川省成都市武侯区望江路29号,四川大学生命科学学院B610

欢迎感兴趣的研究生、博士生和博士后联系！

个人简介:

长期从事间质细胞的命运重编程及其在矿化组织器官发育和损伤修复方面的调控研究，研究成果在Science Advances, Nature Communications, EMBO J, PNAS, Cell Reports, Advanced Science, Genome Biology, Accounts in Chemical Research, Nature Reviews Drug Discovery等国际著名学术期刊上发表，他引超过3600次。当选四川省学术和技术带头人，担任四川省生物化学与分子生物学学会副理事长，中国细胞生物学会青年工作委员会委员、美国毒理学会会员，“细胞黄埔研修班”WLLA论坛召集人等。

学习及工作经历：

2001- 2005 复旦大学，生命科学，本科

2005- 2012 麻省大学医学院，生化和分子制药系，博士

2012- 2014 美国辉瑞制药，药物安全研发部，博士后

2014- 2015 美国辉瑞制药，药物安全研发部，Senior Scientist

2015- 至今 四川大学生命科学学院教授

2017- 至今 兼任生命科学学院副院长

2019- 至今 兼任口腔再生医学国家地方联合工程实验室副主任

科学研究：

1、以正向遗传筛选，研究干细胞定向分化及其调控机制；

2、基于干细胞的体外胚层重组与组织再生（以牙齿、骨再生修复为模型）

代表性论文：                                                            

1. Meng TG*, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH*, Wang ZB*, Wong CL*, Li Z*, Sun QY*. NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Advanced Science (2023) e2301940. IF:17.521

2. Hu H, Duan Y, Wang K, Fu H, Liao Y, Wang T, Zhang Z, Kang F, Zhang B, Zhang H, Huo F, Yin Y, Chen G, Hu H, Cai H*, Tian W*, Li Z*. Dental niche cells directly contribute to tooth reconstitution and morphogenesis. Cell Reports (2022). https://doi.org/10.1016/j.celrep.2022.111737. IF:9.995

3. Zhang Y, Li Z*. RNA binding proteins: Linking mechanotransduction and tumor metastasis. Cancer Lett (2021) 496:30-40. IF:8.679

4. Yin Y, Cao S, Fu H, Fan X, Xiong J, Huang Q, Liu Y, Xie K, Meng TG, Liu Y, Tang D, Yang T, Dong B, Qi S, Nie L, Zhang H, Hu H, Xu W, Li F, Dai L, Sun QY, and Li Z*. A non-canonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis. Proc Natl Acad Sci USA. (2020). 117(36):22237-22248. IF:12.779

5. Chen H, Fu H, Wu X, Duan Y, Zhang S, Hu H, Liao Y, Wang T, Yang Y, Chen G*, Li Z* and Tian W*. Regeneration of pulpo-dentinal-like complex by a group of unique multipotent CD24a positive stem cells. Science Advances (2020). 6(15):eaay1514. IF:14.136

6. Zheng Z, Hu H, Tong Y, Hu Z, Cao S, Shan C, Lin W, Yin Y, Li Z*. MiR-27b regulates podocyte survival through targeting adenosine receptor 2B in podocytes from non-human primate. Cell Death Dis. (2018) 9(11):1133. IF:9.685

7. Li Z, Rana TM. Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol. (2014) 11:979-85. IF:4.766

8. Li Z, Rana TM. Therapeutic Targeting of MicroRNAs: Current Status and Future Challenges. Nat Rev Drug Discov. (2014). 13:622-38. IF:112.288

9. Li Z (co-first), Dang J, Rana TM. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA (2014). 20:1900-15. IF:5.451

10. Li Z (co-first), Chao TC, Chang K, Lin N, Burns JC, Rana TM*. The long non-coding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl Acad Sci USA. (2014). 111:1002-7. IF:12.779

11. Henzler CM, Li Z (co-first), Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM*, Kosik KS*. Staged miRNA re-regulation patterns during reprogramming. Genome Biol. (2013). 14:R149. IF:17.906

12. Li Z, Rana,TM*. A Kinase library screen identifies small molecule activators of iPS cell Reprogramming. Nat Commun. (2012) 3:1085. IF:14.919

13. Li Z, Rana, TM*. Molecular Mechanisms of RNA-triggered Gene Silencing Machineries. Accounts Chem Res. (2012) 45: 1122-31. IF:22.384

14. Li Z, Yang,CS., Nakashima, K., Rana, TM*. Small RNA-mediated regulation of iPS cell Generation. EMBO J (2011) 30:823-34. IF:11.598